Effect of chronic hypoxia on fetal pulmonary vascular contractility

Qin Xue; Charles A Ducsay; Lawrence D Longo; Lubo Zhang

doi:10.1096/fasebj.21.6.A1438-c

Effect of chronic hypoxia on fetal pulmonary vascular contractility

Qin Xue
, Charles A Ducsay
, Lawrence D Longo
, Lubo Zhang

Research output: Contribution to journal › Meeting abstract › peer-review

Abstract

The present study tested the hypothesis that chronic hypoxia differentially regulates contractility of fetal pulmonary arteries and veins. Fourth generation pulmonary arteries and veins were isolated from near‐term fetuses of normoxic control and chronically hypoxic (exposure to high altitude 3,801m for 110 days, PaO2: 60 Torr) pregnant ewes. Chronic hypoxia did not significantly change KCl‐induced contractions. In pulmonary arteries, chronic hypoxia significantly enhanced NE‐induced contractions, increasing the maximal response from 104.6±2.6 to 136.4±4.0 %Kmax (P

Original language	American English
Pages (from-to)	A1438
Journal	The FASEB Journal
Volume	21
Issue number	6
DOIs	https://doi.org/10.1096/fasebj.21.6.A1438-c
State	Published - Apr 1 2007

Disciplines

Cardiology
Internal Medicine
Medicine and Health Sciences

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AU - Ducsay, Charles A

AU - Longo, Lawrence D

AU - Zhang, Lubo

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AB - The present study tested the hypothesis that chronic hypoxia differentially regulates contractility of fetal pulmonary arteries and veins. Fourth generation pulmonary arteries and veins were isolated from near‐term fetuses of normoxic control and chronically hypoxic (exposure to high altitude 3,801m for 110 days, PaO2: 60 Torr) pregnant ewes. Chronic hypoxia did not significantly change KCl‐induced contractions. In pulmonary arteries, chronic hypoxia significantly enhanced NE‐induced contractions, increasing the maximal response from 104.6±2.6 to 136.4±4.0 %Kmax (P

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JO - The FASEB Journal

JF - The FASEB Journal

IS - 6

ER -

Effect of chronic hypoxia on fetal pulmonary vascular contractility

Abstract

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