TY - GEN
T1 - Effect of amantadine sulphate on intracerebral hemorrhage-induced brain injury in rats
AU - Titova, E.
AU - Ostrowski, R. P.
AU - Zhang, J. H.
AU - Tang, J.
N1 - Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA, volume 105) Recent studies have shown that amantadine, an uncompetitive N-methyl-d-aspartate receptor antagonist and dopamine agonist, is effective for the treatment of various cerebral disorders and causes relatively mild side effects.
PY - 2008/11/12
Y1 - 2008/11/12
N2 - Recent studies have shown that amantadine, an uncompetitive N-methyl-d-aspartate receptor antagonist and dopamine agonist, is effective for the treatment of various cerebral disorders and causes relatively mild side effects. In this study, we investigated whether administration of amantadine will provide a neuroprotective effect in the intracerebral hemorrhage (ICH) rat model. A total of 15 male Sprague Dawley rats (300-380 g) were divided into sham, ICH-untreated, and ICH-treated with amantadine sulphate groups. ICH was induced by collagenase injection. Total dose 6mg/kg of amantadine sulphate was divided into 3 injections and administered intraperitoneally at 1, 8, and 16h after ICH. Brain injury was evaluated by investigating neurological function and brain edema at 24 h after ICH. Our data demonstrates that ICH caused significant neurological deficit associated with marked brain edema. Amantadine did not reduce brain injury after ICH; neurological function and brain edema in the treated group were not different from those of the untreated group. We conclude that amantadine sulphate does not offer neuroprotection in acute stage of experimental ICH-induced brain injury. © 2008 Springer-Verlag.
AB - Recent studies have shown that amantadine, an uncompetitive N-methyl-d-aspartate receptor antagonist and dopamine agonist, is effective for the treatment of various cerebral disorders and causes relatively mild side effects. In this study, we investigated whether administration of amantadine will provide a neuroprotective effect in the intracerebral hemorrhage (ICH) rat model. A total of 15 male Sprague Dawley rats (300-380 g) were divided into sham, ICH-untreated, and ICH-treated with amantadine sulphate groups. ICH was induced by collagenase injection. Total dose 6mg/kg of amantadine sulphate was divided into 3 injections and administered intraperitoneally at 1, 8, and 16h after ICH. Brain injury was evaluated by investigating neurological function and brain edema at 24 h after ICH. Our data demonstrates that ICH caused significant neurological deficit associated with marked brain edema. Amantadine did not reduce brain injury after ICH; neurological function and brain edema in the treated group were not different from those of the untreated group. We conclude that amantadine sulphate does not offer neuroprotection in acute stage of experimental ICH-induced brain injury. © 2008 Springer-Verlag.
KW - Amantadine sulphate
KW - Rats
KW - brain edema
KW - intracerebral hemorrhage
KW - Cerebral Hemorrhage/chemically induced
KW - Male
KW - Functional Laterality
KW - Rats, Sprague-Dawley
KW - Collagenases
KW - Brain Edema/etiology
KW - Animals
KW - Brain Injuries/drug therapy
KW - Neurologic Examination
KW - Time Factors
KW - Amantadine/therapeutic use
KW - Dopamine Agents/therapeutic use
KW - Disease Models, Animal
UR - https://www.scopus.com/pages/publications/64249089200
UR - https://www.scopus.com/pages/publications/64249089200#tab=citedBy
UR - https://www.mendeley.com/catalogue/72d5b78a-f7ae-3d23-a0e5-6ad618614e85/
U2 - 10.1007/978-3-211-09469-3_24
DO - 10.1007/978-3-211-09469-3_24
M3 - Conference contribution
C2 - 19066095
SN - 9783211094686
SN - 978-3-211-99870-0
T3 - Acta Neurochirurgica, Supplementum
SP - 119
EP - 121
BT - Cerebral Hemorrhage
PB - Springer Vienna
ER -