@article{09423a8a43a84ad0b2e5da6564dc83ef,
title = "Early goal-directed therapy in severe sepsis and septic shock revisited: Concepts, controversies, and contemporary findings",
keywords = "Biomarkers, Brain natriuretic peptide, Early goal-directed therapy, Implementation, Lactate, Sepsis bundle, Sepsis outcomes, Septic shock, Severe sepsis",
author = "Otero, \{Ronny M.\} and Bryant Nguyen and Huang, \{David T.\} and Gaieski, \{David F.\} and Munish Goyal and Gunnerson, \{Kyle J.\} and Stephen Trzeciak and Robert Sherwin and Holthaus, \{Christopher V.\} and Tiffany Osborn and Rivers, \{Emanuel P.\}",
note = "Studies of acute myocardial infarction, trauma, and stroke have been translated into improved outcomes by earlier diagnosis and application of therapy at the most proximal stage of hospital presentation. Most therapies for these diseases are instituted prior to admission to an ICU; this approach to the sepsis patient has been lacking.",
year = "2006",
month = nov,
doi = "10.1378/chest.130.5.1579",
language = "English",
volume = "130",
pages = "1579--1595",
journal = "Chest",
issn = "0012-3692",
number = "5",
}