Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms

Dennyson Leandro M. Fonseca; Maj Jäpel; Michael Adu Gyamfi; Igor Salerno Filgueiras; Gabriela Crispim Baiochi; Yuri Ostrinski; Gilad Halpert; Yael Bublil Lavi; Elroy Vojdani; Thayna Silva-Sousa; Júlia Nakanishi Usuda; Juan Carlo Santos e Silva; Paula P. Freire; Adriel Leal Nóbile; Anny Silva Adri; Pedro Marçal Barcelos; Yohan Lucas Gonçalves Corrêa; Fernando Yuri Nery do Vale; Letícia Oliveira Lopes; Solveig Lea Schmidt; Xiaoqing Wang; Carl Vahldieck; Benedikt Fels; Lena F. Schimke; Gustavo Cabral-Miranda; Mario Hiroyuki Hirata; Taj Ali AKhan; Yen Rei A. Yu; Rodrigo J.S. Dalmolin; Howard Amital; Aristo Vojdani; Haroldo Dutra Dias; Helder Nakaya; Hans D. Ochs; Jonathan I. Silverberg; Jason Zimmerman; Israel Zyskind; Avi Z. Rosenberg; Kai Schulze-Forster; Harald Heidecke; Rusan Catar; Guido Moll; Alexander Hackel; Kristina Kusche-Vihrog; Yehuda Shoenfeld; Gabriela Riemekasten; Reza Akbarzadeh; Alexandre H.C. Marques; Otavio Cabral-Marques

doi:10.1038/s41540-025-00488-z

Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms

Dennyson Leandro M. Fonseca, Maj Jäpel, Michael Adu Gyamfi, Igor Salerno Filgueiras, Gabriela Crispim Baiochi, Yuri Ostrinski, Gilad Halpert, Yael Bublil Lavi, Elroy Vojdani, Thayna Silva-Sousa, Júlia Nakanishi Usuda, Juan Carlo Santos e Silva, Paula P. Freire, Adriel Leal Nóbile, Anny Silva Adri, Pedro Marçal Barcelos, Yohan Lucas Gonçalves Corrêa, Fernando Yuri Nery do Vale, Letícia Oliveira Lopes, Solveig Lea SchmidtXiaoqing Wang, Carl Vahldieck, Benedikt Fels, Lena F. Schimke, Gustavo Cabral-Miranda, Mario Hiroyuki Hirata, Taj Ali AKhan, Yen Rei A. Yu, Rodrigo J.S. Dalmolin, Howard Amital, Aristo Vojdani, Haroldo Dutra Dias, Helder Nakaya, Hans D. Ochs, Jonathan I. Silverberg, Jason Zimmerman, Israel Zyskind, Avi Z. Rosenberg, Kai Schulze-Forster, Harald Heidecke, Rusan Catar, Guido Moll, Alexander Hackel, Kristina Kusche-Vihrog, Yehuda Shoenfeld, Gabriela Riemekasten, Reza Akbarzadeh, Alexandre H.C. Marques, Otavio Cabral-Marques

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	7
Journal	NPJ systems biology and applications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41540-025-00488-z
State	Published - Dec 2025
Externally published	Yes

ASJC Scopus Subject Areas

Modeling and Simulation
General Biochemistry,Genetics and Molecular Biology
Drug Discovery
Computer Science Applications
Applied Mathematics

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Fonseca, D. L. M., Jäpel, M., Gyamfi, M. A., Filgueiras, I. S., Baiochi, G. C., Ostrinski, Y., Halpert, G., Lavi, Y. B., Vojdani, E., Silva-Sousa, T., Usuda, J. N., e Silva, J. C. S., Freire, P. P., Nóbile, A. L., Adri, A. S., Barcelos, P. M., Corrêa, Y. L. G., do Vale, F. Y. N., Lopes, L. O., ... Cabral-Marques, O. (2025). Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms. NPJ systems biology and applications, 11(1), Article 7. https://doi.org/10.1038/s41540-025-00488-z

Fonseca, DLM, Jäpel, M, Gyamfi, MA, Filgueiras, IS, Baiochi, GC, Ostrinski, Y, Halpert, G, Lavi, YB, Vojdani, E, Silva-Sousa, T, Usuda, JN, e Silva, JCS, Freire, PP, Nóbile, AL, Adri, AS, Barcelos, PM, Corrêa, YLG, do Vale, FYN, Lopes, LO, Schmidt, SL, Wang, X, Vahldieck, C, Fels, B, Schimke, LF, Cabral-Miranda, G, Hirata, MH, AKhan, TA, Yu, YRA, Dalmolin, RJS, Amital, H, Vojdani, A, Dias, HD, Nakaya, H, Ochs, HD, Silverberg, JI, Zimmerman, J, Zyskind, I, Rosenberg, AZ, Schulze-Forster, K, Heidecke, H, Catar, R, Moll, G, Hackel, A, Kusche-Vihrog, K, Shoenfeld, Y, Riemekasten, G, Akbarzadeh, R, Marques, AHC & Cabral-Marques, O 2025, 'Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms', NPJ systems biology and applications, vol. 11, no. 1, 7. https://doi.org/10.1038/s41540-025-00488-z

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AU - Gyamfi, Michael Adu

AU - Filgueiras, Igor Salerno

AU - Baiochi, Gabriela Crispim

AU - Ostrinski, Yuri

AU - Halpert, Gilad

AU - Lavi, Yael Bublil

AU - Vojdani, Elroy

AU - Silva-Sousa, Thayna

AU - Usuda, Júlia Nakanishi

AU - e Silva, Juan Carlo Santos

AU - Freire, Paula P.

AU - Nóbile, Adriel Leal

AU - Adri, Anny Silva

AU - Barcelos, Pedro Marçal

AU - Corrêa, Yohan Lucas Gonçalves

AU - do Vale, Fernando Yuri Nery

AU - Lopes, Letícia Oliveira

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AU - Vahldieck, Carl

AU - Fels, Benedikt

AU - Schimke, Lena F.

AU - Cabral-Miranda, Gustavo

AU - Hirata, Mario Hiroyuki

AU - AKhan, Taj Ali

AU - Yu, Yen Rei A.

AU - Dalmolin, Rodrigo J.S.

AU - Amital, Howard

AU - Vojdani, Aristo

AU - Dias, Haroldo Dutra

AU - Nakaya, Helder

AU - Ochs, Hans D.

AU - Silverberg, Jonathan I.

AU - Zimmerman, Jason

AU - Zyskind, Israel

AU - Rosenberg, Avi Z.

AU - Schulze-Forster, Kai

AU - Heidecke, Harald

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AU - Moll, Guido

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AU - Kusche-Vihrog, Kristina

AU - Shoenfeld, Yehuda

AU - Riemekasten, Gabriela

AU - Akbarzadeh, Reza

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Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms

ASJC Scopus Subject Areas

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