Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors

Gilda G. Hillman; Vinita Singh-Gupta; Hao Zhang; Areen K. Al-Bashir; Yashwanth Katkuri; Meng Li; Christopher K. Yunker; Amit D. Patel; Judith Abrams; E. Mark Haacke

doi:10.1593/neo.09618

Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors

Gilda G. Hillman
, Vinita Singh-Gupta
, Hao Zhang
, Areen K. Al-Bashir
, Yashwanth Katkuri
, Meng Li
, Christopher K. Yunker
, Amit D. Patel
, Judith Abrams
, E. Mark Haacke

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	910-920
Number of pages	11
Journal	Neoplasia
Volume	11
Issue number	9
DOIs	https://doi.org/10.1593/neo.09618
State	Published - Sep 2009
Externally published	Yes

ASJC Scopus Subject Areas

Cancer Research

Keywords

Immunoprecipitation
Pyrroles/pharmacology
Humans
Vascular Endothelial Growth Factor Receptor-2/metabolism
Capillary Permeability/drug effects
Indoles/pharmacology
Xenograft Model Antitumor Assays
Magnetic Resonance Imaging
Antineoplastic Agents/pharmacology
Sunitinib
Animals
Carcinoma, Renal Cell/blood supply
Contrast Media
Kidney Neoplasms/blood supply
Mice, Nude
Receptors, Platelet-Derived Growth Factor/metabolism
Female
Hypoxia
Mice
Mice, Inbred BALB C
Tumor Cells, Cultured
Neovascularization, Pathologic/prevention & control
Gadolinium DTPA

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10.1593/neo.09618

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@article{a0b54c84936a498887f5ae0709e126f3,

title = "Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors",

keywords = "Immunoprecipitation, Pyrroles/pharmacology, Humans, Vascular Endothelial Growth Factor Receptor-2/metabolism, Capillary Permeability/drug effects, Indoles/pharmacology, Xenograft Model Antitumor Assays, Magnetic Resonance Imaging, Antineoplastic Agents/pharmacology, Sunitinib, Animals, Carcinoma, Renal Cell/blood supply, Contrast Media, Kidney Neoplasms/blood supply, Mice, Nude, Receptors, Platelet-Derived Growth Factor/metabolism, Female, Hypoxia, Mice, Mice, Inbred BALB C, Tumor Cells, Cultured, Neovascularization, Pathologic/prevention \& control, Gadolinium DTPA",

author = "Hillman, \{Gilda G.\} and Vinita Singh-Gupta and Hao Zhang and Al-Bashir, \{Areen K.\} and Yashwanth Katkuri and Meng Li and Yunker, \{Christopher K.\} and Patel, \{Amit D.\} and Judith Abrams and Haacke, \{E. Mark\}",

note = "Funding Information: Abbreviations: RCC, renal cell carcinoma; DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging; ROI, region of interest; IAUC, initial area under the curve; CIAUC, cumulative IAUC; VEGFR-2, vascular endothelial growth factor receptor 2; VEGF, vascular endothelial growth factor; PDGFR-β, platelet-derived growth factor receptor β; KCI-18 RCC, Karmanos Cancer Institute-18 RCC cell line; KCI-18/IK, KCI-18 RCC cell line passaged in mouse kidney; RTK, receptor tyrosine kinase; PFS, progression-free survival; Gd-DTPA, gadolinium diethylene triamine pentaacetic acid; SU10, sunitinib 10 mg/kg per day; SU20, sunitinib 20 mg/kg per day; SU40, sunitinib 40 mg/kg per day; H\&E, hematoxylin-eosin; NK, normal kidney; KT, kidney tumor Address all correspondence to: Gilda G. Hillman, PhD, Department of Radiation Oncology, 515 Hudson-Webber Cancer Research Center, 4100 John R. Road, Detroit, MI 48201. E-mail: [email protected] 1This study was supported by Pfizer grant IIR no. GA61818Z 9 (to G.G. Hillman). Received 14 April 2009; Revised 5 June 2009; Accepted 6 June 2009 Copyright {\textcopyright} 2009 Neoplasia Press, Inc. All rights reserved 1522-8002/09/\$25.00 DOI 10.1593/neo.09618",

year = "2009",

month = sep,

doi = "10.1593/neo.09618",

language = "English",

volume = "11",

pages = "910--920",

journal = "Neoplasia",

issn = "1522-8002",

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T1 - Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors

AU - Hillman, Gilda G.

AU - Singh-Gupta, Vinita

AU - Zhang, Hao

AU - Al-Bashir, Areen K.

AU - Katkuri, Yashwanth

AU - Li, Meng

AU - Yunker, Christopher K.

AU - Patel, Amit D.

AU - Abrams, Judith

AU - Haacke, E. Mark

N1 - Funding Information: Abbreviations: RCC, renal cell carcinoma; DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging; ROI, region of interest; IAUC, initial area under the curve; CIAUC, cumulative IAUC; VEGFR-2, vascular endothelial growth factor receptor 2; VEGF, vascular endothelial growth factor; PDGFR-β, platelet-derived growth factor receptor β; KCI-18 RCC, Karmanos Cancer Institute-18 RCC cell line; KCI-18/IK, KCI-18 RCC cell line passaged in mouse kidney; RTK, receptor tyrosine kinase; PFS, progression-free survival; Gd-DTPA, gadolinium diethylene triamine pentaacetic acid; SU10, sunitinib 10 mg/kg per day; SU20, sunitinib 20 mg/kg per day; SU40, sunitinib 40 mg/kg per day; H&E, hematoxylin-eosin; NK, normal kidney; KT, kidney tumor Address all correspondence to: Gilda G. Hillman, PhD, Department of Radiation Oncology, 515 Hudson-Webber Cancer Research Center, 4100 John R. Road, Detroit, MI 48201. E-mail: [email protected] 1This study was supported by Pfizer grant IIR no. GA61818Z 9 (to G.G. Hillman). Received 14 April 2009; Revised 5 June 2009; Accepted 6 June 2009 Copyright © 2009 Neoplasia Press, Inc. All rights reserved 1522-8002/09/$25.00 DOI 10.1593/neo.09618

PY - 2009/9

Y1 - 2009/9

KW - Immunoprecipitation

KW - Pyrroles/pharmacology

KW - Humans

KW - Vascular Endothelial Growth Factor Receptor-2/metabolism

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KW - Carcinoma, Renal Cell/blood supply

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KW - Female

KW - Hypoxia

KW - Mice

KW - Mice, Inbred BALB C

KW - Tumor Cells, Cultured

KW - Neovascularization, Pathologic/prevention & control

KW - Gadolinium DTPA

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Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors

ASJC Scopus Subject Areas

Keywords

Access to Document

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