Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors

Gilda G. Hillman; Vinita Singh-Gupta; Hao Zhang; Areen K. Al-Bashir; Yashwanth Katkuri; Meng Li; Christopher K. Yunker; Amit D. Patel; Judith Abrams; E. Mark Haacke

doi:10.1593/neo.09618

Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors

Gilda G. Hillman, Vinita Singh-Gupta, Hao Zhang, Areen K. Al-Bashir, Yashwanth Katkuri, Meng Li, Christopher K. Yunker, Amit D. Patel, Judith Abrams, E. Mark Haacke

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	910-920
Number of pages	11
Journal	Neoplasia (United States)
Volume	11
Issue number	9
DOIs	https://doi.org/10.1593/neo.09618
State	Published - Sep 2009
Externally published	Yes

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Cancer Research

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Hillman, G. G., Singh-Gupta, V., Zhang, H., Al-Bashir, A. K., Katkuri, Y., Li, M., Yunker, C. K., Patel, A. D., Abrams, J., & Haacke, E. M. (2009). Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors. Neoplasia (United States), 11(9), 910-920. https://doi.org/10.1593/neo.09618

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title = "Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors",

author = "Hillman, {Gilda G.} and Vinita Singh-Gupta and Hao Zhang and Al-Bashir, {Areen K.} and Yashwanth Katkuri and Meng Li and Yunker, {Christopher K.} and Patel, {Amit D.} and Judith Abrams and Haacke, {E. Mark}",

note = "Funding Information: Abbreviations: RCC, renal cell carcinoma; DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging; ROI, region of interest; IAUC, initial area under the curve; CIAUC, cumulative IAUC; VEGFR-2, vascular endothelial growth factor receptor 2; VEGF, vascular endothelial growth factor; PDGFR-β, platelet-derived growth factor receptor β; KCI-18 RCC, Karmanos Cancer Institute-18 RCC cell line; KCI-18/IK, KCI-18 RCC cell line passaged in mouse kidney; RTK, receptor tyrosine kinase; PFS, progression-free survival; Gd-DTPA, gadolinium diethylene triamine pentaacetic acid; SU10, sunitinib 10 mg/kg per day; SU20, sunitinib 20 mg/kg per day; SU40, sunitinib 40 mg/kg per day; H&E, hematoxylin-eosin; NK, normal kidney; KT, kidney tumor Address all correspondence to: Gilda G. Hillman, PhD, Department of Radiation Oncology, 515 Hudson-Webber Cancer Research Center, 4100 John R. Road, Detroit, MI 48201. E-mail: [email protected] 1This study was supported by Pfizer grant IIR no. GA61818Z 9 (to G.G. Hillman). Received 14 April 2009; Revised 5 June 2009; Accepted 6 June 2009 Copyright {\textcopyright} 2009 Neoplasia Press, Inc. All rights reserved 1522-8002/09/$25.00 DOI 10.1593/neo.09618",

year = "2009",

month = sep,

doi = "10.1593/neo.09618",

language = "English",

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AU - Hillman, Gilda G.

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AU - Zhang, Hao

AU - Al-Bashir, Areen K.

AU - Katkuri, Yashwanth

AU - Li, Meng

AU - Yunker, Christopher K.

AU - Patel, Amit D.

AU - Abrams, Judith

AU - Haacke, E. Mark

N1 - Funding Information: Abbreviations: RCC, renal cell carcinoma; DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging; ROI, region of interest; IAUC, initial area under the curve; CIAUC, cumulative IAUC; VEGFR-2, vascular endothelial growth factor receptor 2; VEGF, vascular endothelial growth factor; PDGFR-β, platelet-derived growth factor receptor β; KCI-18 RCC, Karmanos Cancer Institute-18 RCC cell line; KCI-18/IK, KCI-18 RCC cell line passaged in mouse kidney; RTK, receptor tyrosine kinase; PFS, progression-free survival; Gd-DTPA, gadolinium diethylene triamine pentaacetic acid; SU10, sunitinib 10 mg/kg per day; SU20, sunitinib 20 mg/kg per day; SU40, sunitinib 40 mg/kg per day; H&E, hematoxylin-eosin; NK, normal kidney; KT, kidney tumor Address all correspondence to: Gilda G. Hillman, PhD, Department of Radiation Oncology, 515 Hudson-Webber Cancer Research Center, 4100 John R. Road, Detroit, MI 48201. E-mail: [email protected] 1This study was supported by Pfizer grant IIR no. GA61818Z 9 (to G.G. Hillman). Received 14 April 2009; Revised 5 June 2009; Accepted 6 June 2009 Copyright © 2009 Neoplasia Press, Inc. All rights reserved 1522-8002/09/$25.00 DOI 10.1593/neo.09618

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Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors

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