Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro

William A. Chen; Terry G. Williams; Leena So; Natalie Drew; Jie Fang; Pedro Ochoa; Nhi Nguyen; Yasmeen Jawhar; Jide Otiji; Penelope J. Duerksen-Hughes; Mark E. Reeves; Carlos A. Casiano; Hongjian Jin; Sinisa Dovat; Jun Yang; Kristopher E. Boyle; Olivia L. Francis-Boyle

doi:10.3390/ijms25084342

Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro

William A. Chen
, Terry G. Williams
, Leena So
, Natalie Drew
, Jie Fang
, Pedro Ochoa
, Nhi Nguyen
, Yasmeen Jawhar
, Jide Otiji
, Penelope J. Duerksen-Hughes
, Mark E. Reeves
, Carlos A. Casiano
, Hongjian Jin
, Sinisa Dovat
, Jun Yang
, Kristopher E. Boyle
, Olivia L. Francis-Boyle

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	4342
Journal	International Journal of Molecular Sciences
Volume	25
Issue number	8
DOIs	https://doi.org/10.3390/ijms25084342
State	Published - Apr 2024

ASJC Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

Keywords

DNA alkylation
DNA double-strand break
acute myeloid leukemia
apoptosis
chemotherapy
duocarmycin SA
DNA Breaks, Double-Stranded/drug effects
Humans
Leukemia, Myeloid, Acute/drug therapy
Apoptosis/drug effects
Duocarmycins/pharmacology
Antineoplastic Agents/pharmacology
Cell Line, Tumor
HL-60 Cells
Cell Cycle Checkpoints/drug effects
DNA Damage/drug effects
Cell Proliferation/drug effects

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Chen, W. A., Williams, T. G., So, L., Drew, N., Fang, J., Ochoa, P., Nguyen, N., Jawhar, Y., Otiji, J., Duerksen-Hughes, P. J., Reeves, M. E., Casiano, C. A., Jin, H., Dovat, S., Yang, J., Boyle, K. E., & Francis-Boyle, O. L. (2024). Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro. International Journal of Molecular Sciences, 25(8), Article 4342. https://doi.org/10.3390/ijms25084342

Chen, WA, Williams, TG, So, L, Drew, N, Fang, J, Ochoa, P, Nguyen, N, Jawhar, Y, Otiji, J, Duerksen-Hughes, PJ , Reeves, ME , Casiano, CA, Jin, H, Dovat, S, Yang, J, Boyle, KE & Francis-Boyle, OL 2024, 'Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro', International Journal of Molecular Sciences, vol. 25, no. 8, 4342. https://doi.org/10.3390/ijms25084342

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title = "Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro",

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month = apr,

doi = "10.3390/ijms25084342",

language = "English",

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journal = "International Journal of Molecular Sciences",

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AU - Chen, William A.

AU - Williams, Terry G.

AU - So, Leena

AU - Drew, Natalie

AU - Fang, Jie

AU - Ochoa, Pedro

AU - Nguyen, Nhi

AU - Jawhar, Yasmeen

AU - Otiji, Jide

AU - Duerksen-Hughes, Penelope J.

AU - Reeves, Mark E.

AU - Casiano, Carlos A.

AU - Jin, Hongjian

AU - Dovat, Sinisa

AU - Yang, Jun

AU - Boyle, Kristopher E.

AU - Francis-Boyle, Olivia L.

PY - 2024/4

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KW - DNA double-strand break

KW - acute myeloid leukemia

KW - apoptosis

KW - chemotherapy

KW - duocarmycin SA

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KW - Humans

KW - Leukemia, Myeloid, Acute/drug therapy

KW - Apoptosis/drug effects

KW - Duocarmycins/pharmacology

KW - Antineoplastic Agents/pharmacology

KW - Cell Line, Tumor

KW - HL-60 Cells

KW - Cell Cycle Checkpoints/drug effects

KW - DNA Damage/drug effects

KW - Cell Proliferation/drug effects

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M3 - Article

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AN - SCOPUS:85191419668

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VL - 25

JO - International Journal of Molecular Sciences

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ER -

Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro

ASJC Scopus Subject Areas

Keywords

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