Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro

William A. Chen; Terry G. Williams; Leena So; Natalie Drew; Jie Fang; Pedro Ochoa; Nhi Nguyen; Yasmeen Jawhar; Jide Otiji; Penelope J. Duerksen-Hughes; Mark E. Reeves; Carlos A. Casiano; Hongjian Jin; Sinisa Dovat; Jun Yang; Kristopher E. Boyle; Olivia L. Francis-Boyle

doi:10.3390/ijms25084342

Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro

William A. Chen, Terry G. Williams, Leena So, Natalie Drew, Jie Fang, Pedro Ochoa, Nhi Nguyen, Yasmeen Jawhar, Jide Otiji, Penelope J. Duerksen-Hughes, Mark E. Reeves, Carlos A. Casiano, Hongjian Jin, Sinisa Dovat, Jun Yang, Kristopher E. Boyle, Olivia L. Francis-Boyle

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	4342
Journal	International Journal of Molecular Sciences
Volume	25
Issue number	8
DOIs	https://doi.org/10.3390/ijms25084342
State	Published - Apr 2024

ASJC Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

Keywords

DNA alkylation
DNA double-strand break
acute myeloid leukemia
apoptosis
chemotherapy
duocarmycin SA
DNA Breaks, Double-Stranded/drug effects
Humans
Leukemia, Myeloid, Acute/drug therapy
Apoptosis/drug effects
Duocarmycins/pharmacology
Antineoplastic Agents/pharmacology
Cell Line, Tumor
HL-60 Cells
Cell Cycle Checkpoints/drug effects
DNA Damage/drug effects
Cell Proliferation/drug effects

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Chen, W. A., Williams, T. G., So, L., Drew, N., Fang, J., Ochoa, P., Nguyen, N., Jawhar, Y., Otiji, J., Duerksen-Hughes, P. J., Reeves, M. E., Casiano, C. A., Jin, H., Dovat, S., Yang, J., Boyle, K. E., & Francis-Boyle, O. L. (2024). Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro. International Journal of Molecular Sciences, 25(8), Article 4342. https://doi.org/10.3390/ijms25084342

Chen, WA, Williams, TG, So, L, Drew, N, Fang, J, Ochoa, P, Nguyen, N, Jawhar, Y, Otiji, J, Duerksen-Hughes, PJ , Reeves, ME , Casiano, CA, Jin, H, Dovat, S, Yang, J, Boyle, KE & Francis-Boyle, OL 2024, 'Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro', International Journal of Molecular Sciences, vol. 25, no. 8, 4342. https://doi.org/10.3390/ijms25084342

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AU - Drew, Natalie

AU - Fang, Jie

AU - Ochoa, Pedro

AU - Nguyen, Nhi

AU - Jawhar, Yasmeen

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AU - Duerksen-Hughes, Penelope J.

AU - Reeves, Mark E.

AU - Casiano, Carlos A.

AU - Jin, Hongjian

AU - Dovat, Sinisa

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KW - Antineoplastic Agents/pharmacology

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Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro

ASJC Scopus Subject Areas

Keywords

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