Abstract
Contradictory reports exist regarding the effects of hyperbaric oxygen (HBO2) on immune functions. We hypothesized that the intensity of exposure is a key factor, which leads to the different effects of HBO2 on immunity. In this study, we determined the function of rat splenic lymphocytes after in vitro exposure to different pressure-durations of HBO2. The proliferation rate and total cytotoxic T lymphocyte (CTL) activity stimulated by concanavalin A were enhanced by exposure to low (100 kPa for 60 or 90 minutes and 150 kPa for 30 or 60 minutes) HBO2 pressure-durations, but were inhibited by exposure to higher pressure-durations. We conclude that HBO2 exerts dual effects on lymphocyte function, as appropriate exposure promotes and excessive exposure inhibits the functions.
| Original language | American English |
|---|---|
| Pages (from-to) | 155-160 |
| Number of pages | 6 |
| Journal | Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc |
| Volume | 36 |
| Issue number | 3 |
| State | Published - May 2009 |
ASJC Scopus Subject Areas
- Pulmonary and Respiratory Medicine
- Physiology (medical)
Keywords
- Animals
- Immunity, Cellular/drug effects
- Time Factors
- Oxygen/pharmacology
- Rats
- Male
- Cell Proliferation/drug effects
- T-Lymphocytes, Cytotoxic/drug effects
- Rats, Sprague-Dawley
- Hyperbaric Oxygenation
- Spleen/cytology
Disciplines
- Biology
- Immunology and Infectious Disease
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