TY - CHAP
T1 - Drill Hole Defects
T2 - Induction, Imaging, and Analysis in the Rodent
AU - Obenaus, Andre
AU - Hayes, Pedro
N1 - Publisher Copyright:
© 2011, Springer Science+Business Media, LLC.
PY - 2011
Y1 - 2011
N2 - Advances in stem therapy, scaffolds, and therapeutic biomolecules are accelerating bone repair research, and model systems are required to test new methods and concepts. The drill hole defect is one such model and is used to study a variety of bone defects and potential therapies designed to repair these injuries. We detail the methodologies required to successfully generate and evaluate drill hole defects. Although performing a successful drill hole defect requires patience and dexterity, investing the time to perfect the technique will provide ample opportunity for the researcher to expand his/her particular research interests. Mastering this technique will allow testing of stem cell therapies, novel scaffold designs, and biomolecules that can be used for clinical translation.
AB - Advances in stem therapy, scaffolds, and therapeutic biomolecules are accelerating bone repair research, and model systems are required to test new methods and concepts. The drill hole defect is one such model and is used to study a variety of bone defects and potential therapies designed to repair these injuries. We detail the methodologies required to successfully generate and evaluate drill hole defects. Although performing a successful drill hole defect requires patience and dexterity, investing the time to perfect the technique will provide ample opportunity for the researcher to expand his/her particular research interests. Mastering this technique will allow testing of stem cell therapies, novel scaffold designs, and biomolecules that can be used for clinical translation.
KW - Computerized tomography
KW - Drill hole defect
KW - Magnetic resonance imaging
KW - Stereotaxic
KW - Surgery
KW - Bone and Bones/pathology
KW - Imaging, Three-Dimensional/methods
KW - Rodentia
KW - Rats
KW - Tomography, X-Ray Computed
KW - Magnetic Resonance Imaging
KW - Animals
KW - Anesthesia
KW - Mice
KW - Disease Models, Animal
UR - https://www.scopus.com/pages/publications/79952199663
UR - https://www.scopus.com/pages/publications/79952199663#tab=citedBy
UR - https://www.mendeley.com/catalogue/cd520763-ad88-35c7-87dc-d84d175e0862/
U2 - 10.1007/978-1-60761-962-8_20
DO - 10.1007/978-1-60761-962-8_20
M3 - Chapter
C2 - 21043001
SN - 9781607619611
T3 - Methods in Molecular Biology
SP - 301
EP - 314
BT - Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases
PB - Humana Press Inc.
ER -