Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features

Fabio J. Pacheco; Frankis G. Almaguel; Whitney Evans; Leslimar Rios-Colon; Valery Filippov; Lai S. Leoh; Elizabeth Rook-Arena; Melanie Mediavilla-Varela; Marino De Leon; Carlos A. Casiano

doi:10.1007/s00011-014-0760-2

Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features

Fabio J. Pacheco
, Frankis G. Almaguel
, Whitney Evans
, Leslimar Rios-Colon
, Valery Filippov
, Lai S. Leoh
, Elizabeth Rook-Arena
, Melanie Mediavilla-Varela
, Marino De Leon
, Carlos A. Casiano

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	859-871
Number of pages	13
Journal	Inflammation Research
Volume	63
Issue number	10
DOIs	https://doi.org/10.1007/s00011-014-0760-2
State	Published - Oct 2014

ASJC Scopus Subject Areas

Immunology
Pharmacology

Keywords

DHA
Inflammation
L929 cells
Lysosomes
Necroptosis
Oxidative stress
TNF-α
Ceramides/metabolism
Reactive Oxygen Species/metabolism
Cell Line
Docosahexaenoic Acids/pharmacology
Necrosis/chemically induced
Apoptosis/drug effects
Autophagy
Tumor Necrosis Factor-alpha
Oxidative Stress/drug effects
Lysosomes/drug effects
Animals
Mice

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Pacheco, F. J., Almaguel, F. G., Evans, W., Rios-Colon, L., Filippov, V., Leoh, L. S., Rook-Arena, E., Mediavilla-Varela, M., De Leon, M., & Casiano, C. A. (2014). Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features. Inflammation Research, 63(10), 859-871. https://doi.org/10.1007/s00011-014-0760-2

Pacheco, FJ, Almaguel, FG, Evans, W, Rios-Colon, L, Filippov, V, Leoh, LS, Rook-Arena, E, Mediavilla-Varela, M, De Leon, M & Casiano, CA 2014, 'Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features', Inflammation Research, vol. 63, no. 10, pp. 859-871. https://doi.org/10.1007/s00011-014-0760-2

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AU - Evans, Whitney

AU - Rios-Colon, Leslimar

AU - Filippov, Valery

AU - Leoh, Lai S.

AU - Rook-Arena, Elizabeth

AU - Mediavilla-Varela, Melanie

AU - De Leon, Marino

AU - Casiano, Carlos A.

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KW - Apoptosis/drug effects

KW - Autophagy

KW - Tumor Necrosis Factor-alpha

KW - Oxidative Stress/drug effects

KW - Lysosomes/drug effects

KW - Animals

KW - Mice

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Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features

ASJC Scopus Subject Areas

Keywords

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