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Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number1476
Pages (from-to)68
Number of pages1
JournalMolecular Cancer
Volume8
DOIs
StatePublished - Aug 28 2009

ASJC Scopus Subject Areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

Keywords

  • Caspase 3/metabolism
  • Prostatic Neoplasms/genetics
  • Cathepsin B/antagonists & inhibitors
  • Humans
  • Intercellular Signaling Peptides and Proteins/genetics
  • Immunoblotting
  • Male
  • Cell Survival/drug effects
  • Cell Cycle/drug effects
  • Dose-Response Relationship, Drug
  • Lysosomes/drug effects
  • Antineoplastic Agents/pharmacology
  • Flow Cytometry
  • Transfection
  • Time Factors
  • Amino Acid Chloromethyl Ketones/pharmacology
  • Enzyme Activation/drug effects
  • TNF-Related Apoptosis-Inducing Ligand/metabolism
  • Apoptosis/drug effects
  • Docetaxel
  • Taxoids/pharmacology
  • Caspase Inhibitors
  • Cysteine Proteinase Inhibitors/pharmacology
  • Membrane Potential, Mitochondrial/drug effects
  • Caspases/metabolism
  • Caspase 2/metabolism
  • Cell Line, Tumor

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