TY - JOUR
T1 - Distortion product otoacoustic emissions show exceptional resistance to noise exposure in MOLF/Ei mice
AU - Candreia, Claudia
AU - Martin, Glen K.
AU - Stagner, Barden B.
AU - Lonsbury-Martin, Brenda L.
N1 - Funding Information:
This research was supported in part by funds from the National Institutes of Health (DC000613, DC003114, DC004476), the University of Miami Chandler Chair Fund (G.K.M., B.B.S., B.L.M.), and the Swiss National Science Foundation and Uarda Fruitiger Fund of Basel (C.C.).
PY - 2004/8
Y1 - 2004/8
N2 - Baseline distortion-product otoacoustic emissions (DPOAEs) at several primary-tone levels were compared between naive 2- to 3-month old inbred CBA/CaJ (CBA) and wild-derived MOLF/Ei (MOLF) mice. Only minor DPOAE differences were noted between the two strains and these differences were not systematic across frequency or test levels. These emission findings were consistent with earlier results on auditory brainstem response thresholds reported by others [Zheng et al., Hear. Res. 130 (1999) 94-107] thus suggesting that both CBA and MOLF strains have normal hearing. Subsequent episodes of over-exposure to a 105-dB SPL, octave-band noise centered at 10 kHz for 8 h revealed that MOLF DPOAEs were exceptionally resistant to the adverse aftereffects of excessive noise exposure as compared to CBA mice. Unlike the noise-exposure resistant inbred 129/SvEvTac strain, which has reduced baseline DPOAE levels especially at high frequencies, MOLF mice have normal DPOAEs making the interpretation of noise-exposure effects more straightforward.
AB - Baseline distortion-product otoacoustic emissions (DPOAEs) at several primary-tone levels were compared between naive 2- to 3-month old inbred CBA/CaJ (CBA) and wild-derived MOLF/Ei (MOLF) mice. Only minor DPOAE differences were noted between the two strains and these differences were not systematic across frequency or test levels. These emission findings were consistent with earlier results on auditory brainstem response thresholds reported by others [Zheng et al., Hear. Res. 130 (1999) 94-107] thus suggesting that both CBA and MOLF strains have normal hearing. Subsequent episodes of over-exposure to a 105-dB SPL, octave-band noise centered at 10 kHz for 8 h revealed that MOLF DPOAEs were exceptionally resistant to the adverse aftereffects of excessive noise exposure as compared to CBA mice. Unlike the noise-exposure resistant inbred 129/SvEvTac strain, which has reduced baseline DPOAE levels especially at high frequencies, MOLF mice have normal DPOAEs making the interpretation of noise-exposure effects more straightforward.
KW - 129, 129/SvEvTac or 129S6 inbred mutant mouse strain
KW - ABR, auditory brainstem response
KW - AHL, age-related hearing loss
KW - Ahl, gene on chromosome 10 that contributes to age-related hearing loss
KW - CBA, CBA/CaJ inbred mouse strain
UR - https://www.scopus.com/pages/publications/3343010627
UR - https://www.scopus.com/pages/publications/3343010627#tab=citedBy
U2 - 10.1016/j.heares.2004.04.007
DO - 10.1016/j.heares.2004.04.007
M3 - Article
C2 - 15276682
SN - 0378-5955
VL - 194
SP - 109
EP - 117
JO - Hearing Research
JF - Hearing Research
IS - 1-2
ER -