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Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis

  • Jing Jing Wang
  • , Fan Liu
  • , Fan Yang
  • , Yi Zhi Wang
  • , Xin Qi
  • , Ying Li
  • , Qin Hu
  • , Michael X. Zhu
  • , Tian Le Xu

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number475
JournalNature Communications
Volume11
Issue number1
DOIs
StatePublished - Jan 24 2020
Externally publishedYes

ASJC Scopus Subject Areas

  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology
  • General
  • General Physics and Astronomy

Keywords

  • Signal Transduction
  • Mice, Inbred C57BL
  • N-Ethylmaleimide-Sensitive Proteins/pharmacology
  • Acidosis/pathology
  • Models, Molecular
  • Necroptosis/physiology
  • Peptide Fragments/chemistry
  • Male
  • Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & inhibitors
  • Neurons/cytology
  • Mice, Knockout
  • Animals
  • Neuroprotection/drug effects
  • Stroke/pathology
  • Female
  • Protein Conformation
  • Mice
  • Protein Interaction Domains and Motifs
  • Models, Neurological
  • Acid Sensing Ion Channels/chemistry
  • Amino Acid Substitution

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