Discovery of NFκB2-Coordinated Dual Regulation of Mitochondrial and Nuclear Genomes Leads to an Effective Therapy for Acute Myeloid Leukemia

Yi Xu, David J. Baylink, Jeffrey Xiao, Lily Tran, Vinh Nguyen, Brandon Park, Ismael Valladares, Scott Lee, Kevin Codorniz, Laren Tan, Chien Shing Chen, Hisham Abdel-Azim, Mark E. Reeves, Hamid Mirshahidi, Guido Marcucci, Huynh Cao

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number8532
JournalInternational Journal of Molecular Sciences
Volume25
Issue number15
DOIs
StatePublished - Aug 2024

ASJC Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Keywords

  • AML
  • ATP
  • FLT3
  • NFκB2
  • NRF1
  • TFAM
  • gilteritinib
  • metabolism
  • mitochondrion
  • Promoter Regions, Genetic
  • Cell Nucleus/metabolism
  • Mitochondria/metabolism
  • Humans
  • Transcription Factors/genetics
  • Gene Expression Regulation, Leukemic
  • DNA-Binding Proteins/genetics
  • Cell Line, Tumor
  • Mitochondrial Proteins/genetics
  • Genome, Mitochondrial
  • Leukemia, Myeloid, Acute/genetics

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