Abstract
Refinements in histologic criteria, staging systems (American Joint Committee on Cancer 8th edition, Brigham and Women's Hospital), clinical guidelines (National Comprehensive Cancer Network [NCCN]), and molecular tools like gene expression profiling have enhanced the precision of cutaneous squamous cell carcinoma diagnosis and treatment. In Merkel cell carcinoma, recent updates in viral pathogenesis, immunohistochemistry, and emerging biomarkers have aided in better diagnostics. As immunotherapies and precision oncology evolve, dermatopathologists remain essential in guiding patient-specific management strategies for both cutaneous squamous cell carcinoma and Merkel cell carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 221-231 |
| Number of pages | 11 |
| Journal | Dermatologic Clinics |
| Volume | 44 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2026 |
ASJC Scopus Subject Areas
- Dermatology
Keywords
- AJCC8 and BWH staging systems
- Cutaneous squamous cell carcinoma
- Gene expression profiles
- Immunohistochemistry
- Merkel cell carcinoma
- NCCN guidelines
- Humans
- Gene Expression Profiling
- Cutaneous Squamous Cell Carcinoma
- Skin Neoplasms/pathology
- Carcinoma, Squamous Cell/pathology
- Carcinoma, Merkel Cell/pathology
- Neoplasm Staging
- Biomarkers, Tumor/metabolism
- Non-Melanoma Skin Neoplasms
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