TY - JOUR
T1 - Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of the aryl hydrocarbon receptor
AU - Wauchope, Shaniece
AU - Roy, Monika A.
AU - Irvine, William
AU - Morrison, Isaac
AU - Brantley, Eileen
AU - Gossell-Williams, Maxine
AU - Timme-Laragy, Alicia R.
AU - Delgoda, Rupika
N1 - Copyright © 2021 Elsevier Inc. All rights reserved.
PY - 2021/5/15
Y1 - 2021/5/15
KW - AHR pathway
KW - Aryl hydrocarbon receptor
KW - CYP1
KW - Carcinogenesis
KW - Chemoprevention
KW - Cytochrome P450 1
KW - Dibenzyl trisulfide
KW - Ethnomedicine
KW - Petiveria alliacea
KW - Activation, Metabolic
KW - Benzo(a)pyrene/metabolism
KW - Humans
KW - Benzyl Compounds/metabolism
KW - Zebrafish Proteins/genetics
KW - Cytochrome P-450 CYP1A1/antagonists & inhibitors
KW - Sulfides/metabolism
KW - Zebrafish/embryology
KW - Binding Sites
KW - Binding, Competitive
KW - Catalytic Domain
KW - Receptors, Aryl Hydrocarbon/genetics
KW - Gene Expression Regulation
KW - Animals
KW - Protein Binding
KW - Cytochrome P-450 Enzyme Inhibitors/metabolism
KW - Cytochrome P-450 CYP1B1/antagonists & inhibitors
KW - Polychlorinated Biphenyls/metabolism
UR - https://www.scopus.com/pages/publications/85103626088
UR - https://www.scopus.com/pages/publications/85103626088#tab=citedBy
UR - https://www.mendeley.com/catalogue/10407bfe-13c4-358d-8d02-0c1e621117ed/
U2 - 10.1016/j.taap.2021.115502
DO - 10.1016/j.taap.2021.115502
M3 - Article
C2 - 33774063
AN - SCOPUS:85103626088
SN - 0041-008X
VL - 419
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
M1 - 115502
ER -