Dexamethasone treatment of newborn rats decreases cardiomyocyte endowment in the developing heart through epigenetic modifications

Maresha S. Gay, Yong Li, Fuxia Xiong, Thant Lin, Lubo Zhang

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article numbere0125033
Pages (from-to)e0125033
JournalPLoS ONE
Volume10
Issue number4
DOIs
StatePublished - Apr 29 2015

ASJC Scopus Subject Areas

  • General

Keywords

  • Animals, Newborn
  • Dexamethasone/administration & dosage
  • Cyclin D2/biosynthesis
  • Epigenesis, Genetic
  • Humans
  • Myocytes, Cardiac/drug effects
  • Rats
  • Cyclin-Dependent Kinase Inhibitor p27/biosynthesis
  • Gene Expression Regulation, Developmental/drug effects
  • Receptors, Glucocorticoid/biosynthesis
  • Animals
  • Heart/drug effects
  • Mifepristone/administration & dosage
  • DNA Methylation/drug effects
  • Cell Proliferation/drug effects

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