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Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant

  • Isabel López-García
  • , Domokos Gerő
  • , Bartosz Szczesny
  • , Petra Szoleczky
  • , Gabor Olah
  • , Katalin Módis
  • , Kangling Zhang
  • , Jungling Gao
  • , Ping Wu
  • , Lawrence C. Sowers
  • , Doug DeWitt
  • , Donald S. Prough
  • , Csaba Szabo

Research output: Contribution to journal › Article › peer-review

Original languageEnglish
Pages (from-to)284-300
Number of pages17
JournalBritish Journal of Pharmacology
Volume175
Issue number2
DOIs
StatePublished - Jan 2018
Externally publishedYes

ASJC Scopus Subject Areas

  • Pharmacology

Keywords

  • Rifampin/pharmacology
  • Mitochondria/metabolism
  • Humans
  • Hydrogen Peroxide
  • L-Lactate Dehydrogenase/metabolism
  • Apoptosis/drug effects
  • Stress, Mechanical
  • Brain Injuries, Traumatic/drug therapy
  • Neuroprotective Agents/pharmacology
  • Animals
  • Drug Evaluation, Preclinical/methods
  • Cell Line, Tumor
  • Cell Death/drug effects
  • Disease Models, Animal
  • Tetrazolium Salts/metabolism

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