TY - JOUR
T1 - Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14
AU - Wang, Hongjie
AU - Li, Zong Yi
AU - Liu, Ying
AU - Persson, Jonas
AU - Beyer, Ines
AU - Möller, Thomas
AU - Koyuncu, Dilara
AU - Drescher, Max R.
AU - Strauss, Robert
AU - Zhang, Xiao Bing
AU - Wahl, James K.
AU - Urban, Nicole
AU - Drescher, Charles
AU - Hemminki, Akseli
AU - Fender, Pascal
AU - Lieber, André
N1 - Funding Information:
This work was supported by US National Institutes of Health grants R01 CA080192 and R01 HLA078836 and Pacific Ovarian Cancer Research Consortium/Specialized Program of Research Excellence in Ovarian Cancer Grant P50 CA83636. We thank R. van Rensburg for critical comments and the Functional Genomics Core at the Center for Ecogenetics and Environmental Health, School of Public Health University of Washington for array analysis.
PY - 2011/1
Y1 - 2011/1
N2 - We have identified desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions. This opening improves access to receptors, for example, CD46 and Her2/neu, that are trapped in intercellular junctions. In addition to complete virions, dodecahedral particles (PtDds), formed by excess amounts of viral capsid proteins, penton base and fiber during viral replication, can trigger DSG-2-mediated opening of intercellular junctions as shown by studies with recombinant Ad3 PtDds. Our findings shed light on adenovirus biology and pathogenesis and may have implications for cancer therapy.
AB - We have identified desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions. This opening improves access to receptors, for example, CD46 and Her2/neu, that are trapped in intercellular junctions. In addition to complete virions, dodecahedral particles (PtDds), formed by excess amounts of viral capsid proteins, penton base and fiber during viral replication, can trigger DSG-2-mediated opening of intercellular junctions as shown by studies with recombinant Ad3 PtDds. Our findings shed light on adenovirus biology and pathogenesis and may have implications for cancer therapy.
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U2 - 10.1038/nm.2270
DO - 10.1038/nm.2270
M3 - Article
C2 - 21151137
SN - 1078-8956
VL - 17
SP - 96
EP - 104
JO - Nature Medicine
JF - Nature Medicine
IS - 1
ER -