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Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

  • Lei Bao
  • , Shu Jen Chen
  • , Kathleen Conrad
  • , Kerry Keefer
  • , Thomas Abraham
  • , John P. Lee
  • , Ju Fang Wang
  • , Xue Qian Zhang
  • , Iwona Hirschler-Laszkiewicz
  • , Hong Gang Wang
  • , Sinisa Dovat
  • , Brian Gans
  • , Muniswamy Madesh
  • , Joseph Y. Cheung
  • , Barbara A. Miller

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)24449-24464
Number of pages16
JournalJournal of Biological Chemistry
Volume291
Issue number47
DOIs
StatePublished - Nov 18 2016
Externally publishedYes

ASJC Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Keywords

  • Reactive Oxygen Species/metabolism
  • Superoxide Dismutase/genetics
  • Calcium
  • Cell Survival
  • Humans
  • Superoxide Dismutase 2
  • Mutation, Missense
  • Neuroblastoma/genetics
  • Gene Deletion
  • Mitochondria/genetics
  • Neoplasm Proteins/genetics
  • Cell Line, Tumor
  • Glycolysis
  • TRPM Cation Channels/genetics
  • Calcium Signaling
  • Amino Acid Substitution

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