Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

Lei Bao; Shu Jen Chen; Kathleen Conrad; Kerry Keefer; Thomas Abraham; John P. Lee; Ju Fang Wang; Xue Qian Zhang; Iwona Hirschler-Laszkiewicz; Hong Gang Wang; Sinisa Dovat; Brian Gans; Muniswamy Madesh; Joseph Y. Cheung; Barbara A. Miller

doi:10.1074/jbc.M116.747147

Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

Lei Bao, Shu Jen Chen, Kathleen Conrad, Kerry Keefer, Thomas Abraham, John P. Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Hong Gang Wang, Sinisa Dovat, Brian Gans, Muniswamy Madesh, Joseph Y. Cheung, Barbara A. Miller

Biochemistry Division

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	24449-24464
Number of pages	16
Journal	Journal of Biological Chemistry
Volume	291
Issue number	47
DOIs	https://doi.org/10.1074/jbc.M116.747147
State	Published - Nov 18 2016

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

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Bao, L., Chen, S. J., Conrad, K., Keefer, K., Abraham, T., Lee, J. P., Wang, J. F., Zhang, X. Q., Hirschler-Laszkiewicz, I., Wang, H. G., Dovat, S., Gans, B., Madesh, M., Cheung, J. Y., & Miller, B. A. (2016). Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics. Journal of Biological Chemistry, 291(47), 24449-24464. https://doi.org/10.1074/jbc.M116.747147

Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics. / Bao, Lei; Chen, Shu Jen; Conrad, Kathleen et al.
In: Journal of Biological Chemistry, Vol. 291, No. 47, 18.11.2016, p. 24449-24464.

Research output: Contribution to journal › Article › peer-review

Bao, L, Chen, SJ, Conrad, K, Keefer, K, Abraham, T, Lee, JP, Wang, JF, Zhang, XQ, Hirschler-Laszkiewicz, I, Wang, HG, Dovat, S, Gans, B, Madesh, M, Cheung, JY & Miller, BA 2016, 'Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics', Journal of Biological Chemistry, vol. 291, no. 47, pp. 24449-24464. https://doi.org/10.1074/jbc.M116.747147

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AU - Abraham, Thomas

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AU - Wang, Hong Gang

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AU - Gans, Brian

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Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

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