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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

  • Konrad Talbot
  • , Hoau Yan Wang
  • , Hala Kazi
  • , Li Ying Han
  • , Kalindi P. Bakshi
  • , Andres Stucky
  • , Robert L. Fuino
  • , Krista R. Kawaguchi
  • , Andrew J. Samoyedny
  • , Robert S. Wilson
  • , Zoe Arvanitakis
  • , Julie A. Schneider
  • , Bryan A. Wolf
  • , David A. Bennett
  • , John Q. Trojanowski
  • , Steven E. Arnold

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1316-1338
Number of pages23
JournalJournal of Clinical Investigation
Volume122
Issue number4
DOIs
StatePublished - Apr 2 2012
Externally publishedYes

ASJC Scopus Subject Areas

  • General Medicine

Keywords

  • Cerebellar Cortex/metabolism
  • Insulin-Like Growth Factor I/pharmacology
  • Phosphorylation
  • Signal Transduction
  • Humans
  • Middle Aged
  • Recombinant Proteins/pharmacology
  • Insulin Resistance
  • Cognition Disorders/etiology
  • Male
  • Phosphoserine/metabolism
  • Insulin Receptor Substrate Proteins/chemistry
  • Apolipoprotein E4/genetics
  • Brain/drug effects
  • Hippocampus/metabolism
  • Insulin/metabolism
  • Aged, 80 and over
  • Female
  • Aged
  • Glucose/metabolism
  • Protein Processing, Post-Translational
  • Diabetes Complications/complications
  • Alzheimer Disease/metabolism
  • Drug Resistance

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