Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot; Hoau Yan Wang; Hala Kazi; Li Ying Han; Kalindi P. Bakshi; Andres Stucky; Robert L. Fuino; Krista R. Kawaguchi; Andrew J. Samoyedny; Robert S. Wilson; Zoe Arvanitakis; Julie A. Schneider; Bryan A. Wolf; David A. Bennett; John Q. Trojanowski; Steven E. Arnold

doi:10.1172/JCI59903

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, Hoau Yan Wang, Hala Kazi, Li Ying Han, Kalindi P. Bakshi, Andres Stucky, Robert L. Fuino, Krista R. Kawaguchi, Andrew J. Samoyedny, Robert S. Wilson, Zoe Arvanitakis, Julie A. Schneider, Bryan A. Wolf, David A. Bennett, John Q. Trojanowski, Steven E. Arnold

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1316-1338
Number of pages	23
Journal	Journal of Clinical Investigation
Volume	122
Issue number	4
DOIs	https://doi.org/10.1172/JCI59903
State	Published - Apr 2 2012

ASJC Scopus Subject Areas

General Medicine

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Talbot, K., Wang, H. Y., Kazi, H., Han, L. Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., Arvanitakis, Z., Schneider, J. A., Wolf, B. A., Bennett, D. A., Trojanowski, J. Q., & Arnold, S. E. (2012). Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. Journal of Clinical Investigation, 122(4), 1316-1338. https://doi.org/10.1172/JCI59903

Talbot, K, Wang, HY, Kazi, H, Han, LY, Bakshi, KP, Stucky, A, Fuino, RL, Kawaguchi, KR, Samoyedny, AJ, Wilson, RS, Arvanitakis, Z, Schneider, JA, Wolf, BA, Bennett, DA, Trojanowski, JQ & Arnold, SE 2012, 'Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline', Journal of Clinical Investigation, vol. 122, no. 4, pp. 1316-1338. https://doi.org/10.1172/JCI59903

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author = "Konrad Talbot and Wang, {Hoau Yan} and Hala Kazi and Han, {Li Ying} and Bakshi, {Kalindi P.} and Andres Stucky and Fuino, {Robert L.} and Kawaguchi, {Krista R.} and Samoyedny, {Andrew J.} and Wilson, {Robert S.} and Zoe Arvanitakis and Schneider, {Julie A.} and Wolf, {Bryan A.} and Bennett, {David A.} and Trojanowski, {John Q.} and Arnold, {Steven E.}",

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AU - Bakshi, Kalindi P.

AU - Stucky, Andres

AU - Fuino, Robert L.

AU - Kawaguchi, Krista R.

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AU - Wilson, Robert S.

AU - Arvanitakis, Zoe

AU - Schneider, Julie A.

AU - Wolf, Bryan A.

AU - Bennett, David A.

AU - Trojanowski, John Q.

AU - Arnold, Steven E.

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

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