Delayed recanalization in acute ischemic stroke patients: Late is better than never?

Jinwei Pang; John H. Zhang; Yong Jiang

doi:10.1177/0271678X19881449

Delayed recanalization in acute ischemic stroke patients: Late is better than never?

Jinwei Pang, John H. Zhang, Yong Jiang

Physiology Division

Research output: Contribution to journal › Article › peer-review

Abstract

Successful recanalization of the occluded vessel as early as possible has been widely accepted as the key principle of acute ischemic stroke (AIS) treatment. Unfortunately, for many years, the vast majority of AIS patients were prevented from receiving effective recanalization therapy because of a narrow therapeutic window. Recently, a series of inspiring clinical trials have indicated that more patients may benefit from delayed recanalization during an expanded therapeutic window, even up to 24 h after symptom onset. However, could potentially salvageable brain tissue (penumbra) in patients who do not receive medication within 24 h still possible to be saved?

Original language	English
Pages (from-to)	2536-2538
Number of pages	3
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	39
Issue number	12
DOIs	https://doi.org/10.1177/0271678X19881449
State	Published - Dec 1 2019

ASJC Scopus Subject Areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

Keywords

Acute ischemic stroke
clinical trials
delayed recanalization
penumbra
therapeutic window
Brain Ischemia/drug therapy
Time Factors
Humans
Thrombolytic Therapy
Clinical Trials as Topic
Stroke/drug therapy

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title = "Delayed recanalization in acute ischemic stroke patients: Late is better than never?",

abstract = "Successful recanalization of the occluded vessel as early as possible has been widely accepted as the key principle of acute ischemic stroke (AIS) treatment. Unfortunately, for many years, the vast majority of AIS patients were prevented from receiving effective recanalization therapy because of a narrow therapeutic window. Recently, a series of inspiring clinical trials have indicated that more patients may benefit from delayed recanalization during an expanded therapeutic window, even up to 24 h after symptom onset. However, could potentially salvageable brain tissue (penumbra) in patients who do not receive medication within 24 h still possible to be saved?",

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Delayed recanalization in acute ischemic stroke patients: Late is better than never?

Abstract

ASJC Scopus Subject Areas

Keywords

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