TY - JOUR
T1 - Decreased sympathetic innervation of spleen in aged fischer 344 rats
AU - Felten, Suzanne Y.
AU - Bellinger, Denise L.
AU - Collier, Timothy J.
AU - Coleman, Paul D.
AU - Felten, David L.
N1 - Funding Information:
Adult male Fischer 344 rats (from Charles River Labs obtained through the National Institute on Aging) were 1Supported by Grant N00014-84-K-0488 from the Office of Naval Research, 1 F32 NS07980-01 from NIMH (NINCDS), and by NIH Training Grant AG T32 107. ~Requests for reprints should be addressed to Suzanne Y. Felten, Ph.D., Department of Neurobiology and Anatomy, Box 603, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642.
PY - 1987
Y1 - 1987
N2 - Splenic noradrenergic innervation in young adult and aged Fischer 344 rats was examined using fluorescence histochemistry for catecholamines and high performance liquid chromatography with electrochemical detection (LCEC) for the quantitation of norepinephrine (NE). In young adult rats, abundant noradrenergic plexuses followed the vasculature and trabeculae into splenic white pulp. In aged rats, noradrenergic innervation was reduced in density and in overall intensity of fluorescence, and splenic NE levels were significantly lower. The relationship between diminished noradrenergic innervation and diminished immune responsiveness in aging mammals, while not clear on a causal level, is presented as a hypothesis for further testing.
AB - Splenic noradrenergic innervation in young adult and aged Fischer 344 rats was examined using fluorescence histochemistry for catecholamines and high performance liquid chromatography with electrochemical detection (LCEC) for the quantitation of norepinephrine (NE). In young adult rats, abundant noradrenergic plexuses followed the vasculature and trabeculae into splenic white pulp. In aged rats, noradrenergic innervation was reduced in density and in overall intensity of fluorescence, and splenic NE levels were significantly lower. The relationship between diminished noradrenergic innervation and diminished immune responsiveness in aging mammals, while not clear on a causal level, is presented as a hypothesis for further testing.
KW - Aging
KW - Histofluorescence
KW - Immune system Catecholamines
KW - LCEC
KW - Noradrenergic innervation
KW - Spleen
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U2 - 10.1016/0197-4580(87)90026-1
DO - 10.1016/0197-4580(87)90026-1
M3 - Article
C2 - 3587492
SN - 0197-4580
VL - 8
SP - 159
EP - 165
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 2
ER -