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Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas

  • Yi An
  • , Jun Jeon
  • , Lillian Sun
  • , Adeeb Derakhshan
  • , Jianhong Chen
  • , Sophie Carlson
  • , Hui Cheng
  • , Christopher Silvin
  • , Xinping Yang
  • , Carter Van Waes
  • , Zhong Chen

Research output: Contribution to journal › Article › peer-review

Original languageEnglish
Article number6392
JournalScientific Reports
Volume11
Issue number1
DOIs
StatePublished - Mar 18 2021
Externally publishedYes

ASJC Scopus Subject Areas

  • General

Keywords

  • Squamous Cell Carcinoma of Head and Neck/complications
  • Humans
  • Apoptosis/drug effects
  • Dipeptides/pharmacology
  • Male
  • Gene Expression Regulation, Neoplastic/drug effects
  • Baculoviral IAP Repeat-Containing 3 Protein/genetics
  • Tumor Necrosis Factor-alpha/genetics
  • Papillomavirus Infections/complications
  • Indoles/pharmacology
  • Papillomaviridae/pathogenicity
  • Antineoplastic Agents/pharmacology
  • Receptors, TNF-Related Apoptosis-Inducing Ligand/agonists
  • Caspase 8/genetics
  • TNF-Related Apoptosis-Inducing Ligand/genetics
  • Cell Line, Tumor
  • Inhibitor of Apoptosis Proteins/genetics
  • Female
  • Cell Death/drug effects
  • DNA Copy Number Variations/genetics

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