Current ideas about applications of heat shock proteins in vaccine design and immunotherapy

X. Y. Wang; Y. Li; G. Yang; J. R. Subjeck

doi:10.1080/02656730500226407

Current ideas about applications of heat shock proteins in vaccine design and immunotherapy

X. Y. Wang, Y. Li, G. Yang, J. R. Subjeck

Research output: Contribution to journal › Article › peer-review

Abstract

Heat shock proteins (HSPs), as molecular chaperones, perform critical functions in maintaining cell homeostasis. Certain HSPs in extra-cellular milieu are capable of modulating innate and adaptive immunity due to their ability to chaperone polypeptides and to interact with the host's immune system, particularly professional antigen presenting cells (APCs). This review summarizes the immunomodulating functions of HSPs and their potential applications in cancer immunotherapy. © 2005 Taylor & Francis.

Original language	English
Pages (from-to)	717-722
Number of pages	6
Journal	International Journal of Hyperthermia
Volume	21
Issue number	8
DOIs	https://doi.org/10.1080/02656730500226407
State	Published - Dec 2005
Externally published	Yes

ASJC Scopus Subject Areas

Physiology
Physiology (medical)
Cancer Research

Keywords

Cancer immunotherapy
Chaperone
Heat shock proteins
Vaccine
Recombinant Fusion Proteins/genetics
Antigens, Neoplasm/immunology
Humans
Immune System/cytology
Vaccines
Animals
Immunotherapy
Drug Design
Neoplasms/immunology
Heat-Shock Proteins/immunology

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Current ideas about applications of heat shock proteins in vaccine design and immunotherapy

Abstract

ASJC Scopus Subject Areas

Keywords

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