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CTLA-4+ regulatory t cells increased in cetuximab-treated head and neck cancer patients suppress nk cell cytotoxicity and correlate with poor prognosis

  • Hyun Bae Jie
  • , Patrick J. Schuler
  • , Steve C. Lee
  • , Raghvendra M. Srivastava
  • , Athanassios Argiris
  • , Soldano Ferrone
  • , Theresa L. Whiteside
  • , Robert L. Ferris

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)2200-2210
Number of pages11
JournalCancer Research
Volume75
Issue number11
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

ASJC Scopus Subject Areas

  • Oncology
  • Cancer Research

Keywords

  • Cytotoxicity, Immunologic/genetics
  • Prognosis
  • T-Lymphocytes, Regulatory/drug effects
  • Humans
  • Middle Aged
  • Male
  • Gene Expression Regulation, Neoplastic/drug effects
  • Apyrase/biosynthesis
  • CTLA-4 Antigen/biosynthesis
  • Antigens, CD/biosynthesis
  • Antibodies, Monoclonal, Humanized/administration & dosage
  • Forkhead Transcription Factors/biosynthesis
  • Killer Cells, Natural/drug effects
  • Transforming Growth Factor beta/biosynthesis
  • Female
  • Cetuximab
  • Head and Neck Neoplasms/drug therapy
  • Clinical Trials, Phase II as Topic

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