TY - JOUR
T1 - Correlation between subacute sensorimotor deficits and brain water content after surgical brain injury in rats
AU - McBride, Devin W.
AU - Wang, Yuechun
AU - Sherchan, Prativa
AU - Tang, Jiping
AU - Zhang, John H.
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Brain edema is a major contributor to poor outcome and reduced quality of life after surgical brain injury (SBI). Although SBI pathophysiology is well-known, the correlation between cerebral edema and neurological deficits has not been thoroughly examined in the rat model of SBI. Thus, the purpose of this study was to determine the correlation between brain edema and deficits in standard sensorimotor neurobehavior tests for rats subjected to SBI. Sixty male Sprague-Dawley rats were subjected to either sham surgery or surgical brain injury via partial frontal lobectomy. All animals were tested for neurological deficits 24 post-SBI and fourteen were also tested 72. h after surgery using seven common behavior tests: modified Garcia neuroscore (Neuroscore), beam walking, corner turn test, forelimb placement test, adhesive removal test, beam balance test, and foot fault test. After assessing the functional outcome, animals were euthanized for brain water content measurement. Surgical brain injury resulted in significantly elevated frontal lobe brain water content 24 and 72. h after surgery compared to that of sham animals. In all behavior tests, significance was observed between sham and SBI animals. However, a correlation between brain water content and functional outcome was observed for all tests except Neuroscore. The selection of behavior tests is critical to determine the effectiveness of therapeutics. Based on this study's results, we recommend using beam walking, the corner turn test, the beam balance test, and the foot fault test since correlations with brain water content were observed at both 24 and 72. h post-SBI.
AB - Brain edema is a major contributor to poor outcome and reduced quality of life after surgical brain injury (SBI). Although SBI pathophysiology is well-known, the correlation between cerebral edema and neurological deficits has not been thoroughly examined in the rat model of SBI. Thus, the purpose of this study was to determine the correlation between brain edema and deficits in standard sensorimotor neurobehavior tests for rats subjected to SBI. Sixty male Sprague-Dawley rats were subjected to either sham surgery or surgical brain injury via partial frontal lobectomy. All animals were tested for neurological deficits 24 post-SBI and fourteen were also tested 72. h after surgery using seven common behavior tests: modified Garcia neuroscore (Neuroscore), beam walking, corner turn test, forelimb placement test, adhesive removal test, beam balance test, and foot fault test. After assessing the functional outcome, animals were euthanized for brain water content measurement. Surgical brain injury resulted in significantly elevated frontal lobe brain water content 24 and 72. h after surgery compared to that of sham animals. In all behavior tests, significance was observed between sham and SBI animals. However, a correlation between brain water content and functional outcome was observed for all tests except Neuroscore. The selection of behavior tests is critical to determine the effectiveness of therapeutics. Based on this study's results, we recommend using beam walking, the corner turn test, the beam balance test, and the foot fault test since correlations with brain water content were observed at both 24 and 72. h post-SBI.
KW - Brain edema
KW - Experimental models
KW - Neurobehavior tests
KW - Rat model
KW - SBI
KW - Surgical brain injury
KW - Frontal Lobe/chemistry
KW - Rats
KW - Male
KW - Body Water
KW - Rats, Sprague-Dawley
KW - Brain Injuries/complications
KW - Neuropsychological Tests
KW - Neurosurgical Procedures
KW - Brain Edema/etiology
KW - Animals
KW - Behavior, Animal/physiology
KW - Psychomotor Performance/physiology
KW - Disease Models, Animal
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UR - https://www.mendeley.com/catalogue/3e212b35-e510-3ca6-a0f2-b5e940b050f1/
U2 - 10.1016/j.bbr.2015.05.001
DO - 10.1016/j.bbr.2015.05.001
M3 - Article
C2 - 25975171
SN - 0166-4328
VL - 290
SP - 161
EP - 171
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -