TY - CHAP
T1 - Contusion Rodent Model of Traumatic Brain Injury
T2 - Controlled Cortical Impact
AU - Fournier, Marie Line
AU - Clément, Tifenn
AU - Aussudre, Justine
AU - Plesnila, Nikolaus
AU - Obenaus, André
AU - Badaut, Jérôme
N1 - Publisher Copyright:
© 2021, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021
Y1 - 2021
N2 - Traumatic brain injury (TBI) is a heterogeneous brain injury which represents one of the leading causes of mortality and disability worldwide. Rodent TBI models are helpful to examine the cellular and molecular mechanisms after injury. Controlled cortical impact (CCI) is one of the most commonly used TBI models in rats and mice, based on its consistency of injury and ease of implementation. Here, we describe a CCI protocol to induce a moderate contusion to the somatosensory motor cortex. We provide additional protocols for monitoring animals after CCI induction.
AB - Traumatic brain injury (TBI) is a heterogeneous brain injury which represents one of the leading causes of mortality and disability worldwide. Rodent TBI models are helpful to examine the cellular and molecular mechanisms after injury. Controlled cortical impact (CCI) is one of the most commonly used TBI models in rats and mice, based on its consistency of injury and ease of implementation. Here, we describe a CCI protocol to induce a moderate contusion to the somatosensory motor cortex. We provide additional protocols for monitoring animals after CCI induction.
KW - Behavior
KW - Immunohistochemistry
KW - MRI
KW - Pediatric
KW - Traumatic brain injury
KW - Rats
KW - Biological Assay/methods
KW - Animals
KW - Brain Injuries, Traumatic/physiopathology
KW - Contusions/physiopathology
KW - Brain Injuries/physiopathology
KW - Mice
KW - Disease Models, Animal
UR - https://www.scopus.com/pages/publications/85090215759
UR - https://www.scopus.com/pages/publications/85090215759#tab=citedBy
UR - https://www.mendeley.com/catalogue/b2431486-cbe4-3315-a110-628e9dda81d3/
U2 - 10.1007/978-1-0716-0845-6_6
DO - 10.1007/978-1-0716-0845-6_6
M3 - Chapter
C2 - 32808258
T3 - Methods in Molecular Biology
SP - 49
EP - 65
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -