@article{b9e67e2247f94eb194bf4bca227e090f,
title = "Conditional deletion of insulin-like growth factor-I in collagen type 1α2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion",
keywords = "Immunohistochemistry, Collagen Type I/genetics, Bone and Bones/metabolism, Bone Density, Insulin-Like Growth Factor II/genetics, Male, Mice, Transgenic, Tomography, X-Ray Computed, Insulin-Like Growth Factor I/genetics, Reverse Transcriptase Polymerase Chain Reaction, Bone Development/genetics, RNA, Messenger/genetics, Animals, Gene Deletion, Radioimmunoassay, Survival Analysis, Female, Insulin-Like Growth Factor Binding Proteins/genetics, Mice, Body Weight/genetics",
author = "Govoni, \{Kristen E.\} and Wergedal, \{Jon E.\} and Lore Florin and Peter Angel and Baylink, \{David J.\} and Subburaman Mohan",
note = "IGF-I acts through endocrine and local, autocrine/paracrine routes. Disruption of both endocrine and local IGF-I action leads to neonatal lethality and impaired growth in various tissues including bone; however, the severity of growth and skeletal phenotype caused by disruption of endocrine IGF-I action is far less than with total IGF-I disruption.",
year = "2007",
month = dec,
doi = "10.1210/en.2007-0608",
language = "English",
volume = "148",
pages = "5706--5715",
journal = "Endocrinology",
issn = "0013-7227",
number = "12",
}