Concomitant KRAS and BRAF mutations in colorectal cancer

Lauren Midthun; Shagufta Shaheen; Jeremy Deisch; Maheswari Senthil; James Tsai; Chung Tsen Hsueh

doi:10.21037/jgo.2019.01.10

Concomitant KRAS and BRAF mutations in colorectal cancer

Lauren Midthun, Shagufta Shaheen, Jeremy Deisch, Maheswari Senthil, James Tsai, Chung Tsen Hsueh

Research output: Contribution to journal › Article › peer-review

Abstract

BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. While previously considered mutually exclusive, concomitant mutations in both KRAS and BRAF genes have been identified in colorectal cancer (CRC). The clinical outcome of these patients remains undetermined. We present the clinical course of two patients with CRC harboring mutations at codon 12 of KRAS and BRAF non-V600E mutations. More research is needed to determine the clinical-pathological effect of these simultaneous mutations of KRAS and BRAF in CRC on disease course and treatment outcome.

Original language	English
Pages (from-to)	577-581
Number of pages	5
Journal	Journal of Gastrointestinal Oncology
Volume	10
Issue number	3
DOIs	https://doi.org/10.21037/jgo.2019.01.10
State	Published - Jun 2019

ASJC Scopus Subject Areas

Oncology
Gastroenterology

Keywords

BRAF
Colorectal cancer (CRC)
KRAS

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abstract = "BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. While previously considered mutually exclusive, concomitant mutations in both KRAS and BRAF genes have been identified in colorectal cancer (CRC). The clinical outcome of these patients remains undetermined. We present the clinical course of two patients with CRC harboring mutations at codon 12 of KRAS and BRAF non-V600E mutations. More research is needed to determine the clinical-pathological effect of these simultaneous mutations of KRAS and BRAF in CRC on disease course and treatment outcome.",

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AU - Tsai, James

AU - Hsueh, Chung Tsen

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AB - BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. While previously considered mutually exclusive, concomitant mutations in both KRAS and BRAF genes have been identified in colorectal cancer (CRC). The clinical outcome of these patients remains undetermined. We present the clinical course of two patients with CRC harboring mutations at codon 12 of KRAS and BRAF non-V600E mutations. More research is needed to determine the clinical-pathological effect of these simultaneous mutations of KRAS and BRAF in CRC on disease course and treatment outcome.

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KW - Colorectal cancer (CRC)

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Concomitant KRAS and BRAF mutations in colorectal cancer

Abstract

ASJC Scopus Subject Areas

Keywords

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