Combined magnetic fields increased net calcium flux in bone cells

R. J. Fitzsimmons; J. T. Ryaby; F. P. Magee; D. J. Baylink

doi:10.1007/BF00299318

Combined magnetic fields increased net calcium flux in bone cells

R. J. Fitzsimmons
, J. T. Ryaby
, F. P. Magee
, D. J. Baylink

Research output: Contribution to journal › Article › peer-review

Abstract

Low energy electromagnetic fields (EMF) exhibit a large number of biological effects. A major issue to be determined is "What is the lowest threshold of detection in which cells can respond to an EMF?" In these studies we demonstrate that a low-amplitude combined magnetic field (CMF) which induces a maximum potential gradient of 10^-5 V/m is capable of increasing net calcium flux in human osteoblast-like cells. The increase in net calcium flux was frequency dependent, with a peak in the 15.3-16.3 Hz range with an apparent bandwidth of approximately 1 Hz. A model that characterizes the thermal noise limit indicates that nonspherical cell shape, resonant type dynamics, and signal averaging may all play a role in the transduction of lowamplitude EMF effects in biological systems.

Original language	English
Pages (from-to)	376-380
Number of pages	5
Journal	Calcified Tissue International
Volume	55
Issue number	5
DOIs	https://doi.org/10.1007/BF00299318
State	Published - Nov 1994

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Endocrinology

Keywords

Bone
Calcium
Electromagnetic
Osteoblast

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title = "Combined magnetic fields increased net calcium flux in bone cells",

abstract = "Low energy electromagnetic fields (EMF) exhibit a large number of biological effects. A major issue to be determined is {"}What is the lowest threshold of detection in which cells can respond to an EMF?{"} In these studies we demonstrate that a low-amplitude combined magnetic field (CMF) which induces a maximum potential gradient of 10-5 V/m is capable of increasing net calcium flux in human osteoblast-like cells. The increase in net calcium flux was frequency dependent, with a peak in the 15.3-16.3 Hz range with an apparent bandwidth of approximately 1 Hz. A model that characterizes the thermal noise limit indicates that nonspherical cell shape, resonant type dynamics, and signal averaging may all play a role in the transduction of lowamplitude EMF effects in biological systems.",

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note = "Low energy electromagnetic fields (EMF) exhibit a large number of biological effects. A major issue to be determined is {"}What is the lowest threshold of detection in which cells can respond to an EMF?{"} In these studies we demonstrate that a low-amplitude combined magnetic field (CMF) which induces a maximum potential gradient of 10-5 V/m is capable of increasing net calcium flux in human osteoblast-like cells.",

year = "1994",

month = nov,

doi = "10.1007/BF00299318",

language = "English",

volume = "55",

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journal = "Calcified Tissue International",

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AU - Fitzsimmons, R. J.

AU - Ryaby, J. T.

AU - Magee, F. P.

AU - Baylink, D. J.

N1 - Low energy electromagnetic fields (EMF) exhibit a large number of biological effects. A major issue to be determined is "What is the lowest threshold of detection in which cells can respond to an EMF?" In these studies we demonstrate that a low-amplitude combined magnetic field (CMF) which induces a maximum potential gradient of 10-5 V/m is capable of increasing net calcium flux in human osteoblast-like cells.

PY - 1994/11

Y1 - 1994/11

N2 - Low energy electromagnetic fields (EMF) exhibit a large number of biological effects. A major issue to be determined is "What is the lowest threshold of detection in which cells can respond to an EMF?" In these studies we demonstrate that a low-amplitude combined magnetic field (CMF) which induces a maximum potential gradient of 10-5 V/m is capable of increasing net calcium flux in human osteoblast-like cells. The increase in net calcium flux was frequency dependent, with a peak in the 15.3-16.3 Hz range with an apparent bandwidth of approximately 1 Hz. A model that characterizes the thermal noise limit indicates that nonspherical cell shape, resonant type dynamics, and signal averaging may all play a role in the transduction of lowamplitude EMF effects in biological systems.

AB - Low energy electromagnetic fields (EMF) exhibit a large number of biological effects. A major issue to be determined is "What is the lowest threshold of detection in which cells can respond to an EMF?" In these studies we demonstrate that a low-amplitude combined magnetic field (CMF) which induces a maximum potential gradient of 10-5 V/m is capable of increasing net calcium flux in human osteoblast-like cells. The increase in net calcium flux was frequency dependent, with a peak in the 15.3-16.3 Hz range with an apparent bandwidth of approximately 1 Hz. A model that characterizes the thermal noise limit indicates that nonspherical cell shape, resonant type dynamics, and signal averaging may all play a role in the transduction of lowamplitude EMF effects in biological systems.

KW - Bone

KW - Calcium

KW - Electromagnetic

KW - Osteoblast

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DO - 10.1007/BF00299318

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SN - 0171-967X

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EP - 380

JO - Calcified Tissue International

JF - Calcified Tissue International

IS - 5

ER -

Combined magnetic fields increased net calcium flux in bone cells

Abstract

ASJC Scopus Subject Areas

Keywords

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