Cochlear function in mice following inhalation of brevetoxin-3

Janet M. Benson; Barden B. Stagner; Glen K. Martin; Melissa Friedman; Sarah E. Durr; Andrea Gomez; Jacob McDonald; Lora E. Fleming; Lorraine C. Backer; Daniel G. Baden; Andrea Bourdelais; Jerome Naar; Brenda L. Lonsbury-Martin

doi:10.1007/s00359-005-0613-0

Cochlear function in mice following inhalation of brevetoxin-3

Janet M. Benson
, Barden B. Stagner
, Glen K. Martin
, Melissa Friedman
, Sarah E. Durr
, Andrea Gomez
, Jacob McDonald
, Lora E. Fleming
, Lorraine C. Backer
, Daniel G. Baden
, Andrea Bourdelais
, Jerome Naar
, Brenda L. Lonsbury-Martin

Research output: Contribution to journal › Article › peer-review

Abstract

Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f ₁-f ₂ distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 (∼400 μg/m³) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels.

Original language	English
Pages (from-to)	619-626
Number of pages	8
Journal	Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Volume	191
Issue number	7
DOIs	https://doi.org/10.1007/s00359-005-0613-0
State	Published - Jul 2005
Externally published	Yes

ASJC Scopus Subject Areas

Physiology
Ecology, Evolution, Behavior and Systematics
Animal Science and Zoology
Behavioral Neuroscience

Keywords

Brevetoxin
CBA/CaJ mice
Cochlear function
Distortion-product otoacoustic emissions

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10.1007/s00359-005-0613-0

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Benson, J. M., Stagner, B. B., Martin, G. K., Friedman, M., Durr, S. E., Gomez, A., McDonald, J., Fleming, L. E., Backer, L. C., Baden, D. G., Bourdelais, A., Naar, J., & Lonsbury-Martin, B. L. (2005). Cochlear function in mice following inhalation of brevetoxin-3. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, 191(7), 619-626. https://doi.org/10.1007/s00359-005-0613-0

Benson, JM, Stagner, BB, Martin, GK, Friedman, M, Durr, SE, Gomez, A, McDonald, J, Fleming, LE, Backer, LC, Baden, DG, Bourdelais, A, Naar, J & Lonsbury-Martin, BL 2005, 'Cochlear function in mice following inhalation of brevetoxin-3', Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, vol. 191, no. 7, pp. 619-626. https://doi.org/10.1007/s00359-005-0613-0

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title = "Cochlear function in mice following inhalation of brevetoxin-3",

abstract = "Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f 1-f 2 distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 (∼400 μg/m3) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels.",

keywords = "Brevetoxin, CBA/CaJ mice, Cochlear function, Distortion-product otoacoustic emissions",

author = "Benson, \{Janet M.\} and Stagner, \{Barden B.\} and Martin, \{Glen K.\} and Melissa Friedman and Durr, \{Sarah E.\} and Andrea Gomez and Jacob McDonald and Fleming, \{Lora E.\} and Backer, \{Lorraine C.\} and Baden, \{Daniel G.\} and Andrea Bourdelais and Jerome Naar and Lonsbury-Martin, \{Brenda L.\}",

note = "Funding Information: Acknowledgements This research was funded in part by grants from the National Institutes of Health (ES10594, DC00613, DC03114). The authors thank Amber Dison, Carolyn Elliott, Dolores Esparza, Dean Kracko, Colleen Santistevan, and Thomas Argubright for technical assistance. The experiment was conducted in compliance with federal laws of the United States of America and guidance concerning the use of animals in scientific research",

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doi = "10.1007/s00359-005-0613-0",

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AU - Stagner, Barden B.

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AU - McDonald, Jacob

AU - Fleming, Lora E.

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AU - Bourdelais, Andrea

AU - Naar, Jerome

AU - Lonsbury-Martin, Brenda L.

N1 - Funding Information: Acknowledgements This research was funded in part by grants from the National Institutes of Health (ES10594, DC00613, DC03114). The authors thank Amber Dison, Carolyn Elliott, Dolores Esparza, Dean Kracko, Colleen Santistevan, and Thomas Argubright for technical assistance. The experiment was conducted in compliance with federal laws of the United States of America and guidance concerning the use of animals in scientific research

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Cochlear function in mice following inhalation of brevetoxin-3

Abstract

ASJC Scopus Subject Areas

Keywords

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