TY - JOUR
T1 - Chronically lowering sympathetic activity protects sympathetic nerves in spleens from aging F344 rats
AU - Perez, Sam D.
AU - Kozic, Brooke
AU - Molinaro, Christine A.
AU - Thyagarajan, Srinivasan
AU - Ghamsary, Mark
AU - Lubahn, Cheri L.
AU - Lorton, Dianne
AU - Bellinger, Denise L.
N1 - Funding Information:
We thank Servier for graciously providing us with rilmenidine. We also thank Rhoda Gottfried, Sandra Alberto, Jeff Carter, Carlo Wood, Shari Flowers, and Sharda Vyas for their technical assistance. This research was funded by NIH grant, NINDS 44302 .
PY - 2012/6/15
Y1 - 2012/6/15
N2 - In the present study, we investigated how increased sympathetic tone during middle-age affects the splenic sympathetic neurotransmission. Fifteen-month-old (M) F344 rats received rilmenidine (0, 0.5 or 1.5. mg/kg/day, i.p. for 90. days) to lower sympathetic tone. Controls for age were untreated 3 or 18. M rats. We report that rilmenidine (1) reduced plasma and splenic norepinephrine concentrations and splenic norepinephrine turnover, and partially reversed the sympathetic nerve loss; and (2) increased β-adrenergic receptor (β-AR) density and β-AR-stimulated cAMP production. Collectively, these findings suggest a protective effect of lowering sympathetic tone on sympathetic nerve integrity, and enhanced sympathetic neurotransmission in secondary immune organs.
AB - In the present study, we investigated how increased sympathetic tone during middle-age affects the splenic sympathetic neurotransmission. Fifteen-month-old (M) F344 rats received rilmenidine (0, 0.5 or 1.5. mg/kg/day, i.p. for 90. days) to lower sympathetic tone. Controls for age were untreated 3 or 18. M rats. We report that rilmenidine (1) reduced plasma and splenic norepinephrine concentrations and splenic norepinephrine turnover, and partially reversed the sympathetic nerve loss; and (2) increased β-adrenergic receptor (β-AR) density and β-AR-stimulated cAMP production. Collectively, these findings suggest a protective effect of lowering sympathetic tone on sympathetic nerve integrity, and enhanced sympathetic neurotransmission in secondary immune organs.
KW - CAMP production
KW - Imidazoline-1 receptor agonist
KW - Rilmenidine
KW - Splenic norepinephrine turnover
KW - Sympathetic nervous system
KW - β-adrenergic receptors
UR - https://www.scopus.com/pages/publications/84860841205
UR - https://www.scopus.com/pages/publications/84860841205#tab=citedBy
U2 - 10.1016/j.jneuroim.2012.03.022
DO - 10.1016/j.jneuroim.2012.03.022
M3 - Article
C2 - 22546498
SN - 0165-5728
VL - 247
SP - 38
EP - 51
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -