TY - JOUR
T1 - Chronic rhinosinusitis and superantigens
AU - Seiberling, Kristin A.
AU - Grammer, Leslie
AU - Kern, Robert C.
N1 - Atopic Dermatitis Allergy Clin Immunol Nasal Polyp Chronic Rhinosinusitis Nasal Polyposis These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves. This is a preview of subscription content, log in to check access.
PY - 2005/12
Y1 - 2005/12
N2 - This article discusses the potential role of bacterial superantigens (SAgs) in chronic rhinosinusitis with nasal polyposis (CRS/NP). First, it briefly describes SAgs, focusing on how they interact with the immune system by binding to T-cell receptors (TCR) and major histocompatibility complex (MHC) class II molecules. Second, it discusses the role of SAgs in other chronic inflammatory diseases. Finally, it presents evidence for the role of SAgs in the pathogenesis and maintenance of CRS/NP focusing on current research and future considerations. © 2005 Elsevier Inc. All rights reserved.
AB - This article discusses the potential role of bacterial superantigens (SAgs) in chronic rhinosinusitis with nasal polyposis (CRS/NP). First, it briefly describes SAgs, focusing on how they interact with the immune system by binding to T-cell receptors (TCR) and major histocompatibility complex (MHC) class II molecules. Second, it discusses the role of SAgs in other chronic inflammatory diseases. Finally, it presents evidence for the role of SAgs in the pathogenesis and maintenance of CRS/NP focusing on current research and future considerations. © 2005 Elsevier Inc. All rights reserved.
KW - Superantigens/immunology
KW - Humans
KW - Receptors, Antigen, T-Cell/immunology
KW - Rhinitis/immunology
KW - Histocompatibility Antigens Class II/immunology
KW - Nasal Polyps/immunology
KW - Chronic Disease
KW - Sinusitis/immunology
UR - https://www.scopus.com/pages/publications/28444433098
UR - https://www.scopus.com/pages/publications/28444433098#tab=citedBy
UR - https://www.mendeley.com/catalogue/da3bfb97-24ed-3c26-b48d-0ae1c7bea70b/
U2 - 10.1016/j.otc.2005.08.006
DO - 10.1016/j.otc.2005.08.006
M3 - Article
C2 - 16326180
SN - 0030-6665
VL - 38
SP - 1215
EP - 1236
JO - Otolaryngologic Clinics of North America
JF - Otolaryngologic Clinics of North America
IS - 6
ER -