@article{374f4b09edb74dfc99664c49c8b8181e,
title = "Chronic hypoxia and VEGF differentially modulate abundance and organization of myosin heavy chain isoforms in fetal and adult ovine arteries",
keywords = "Confocal colocalization, Nonmuscle myosin heavy chain, Organ culture, Smooth muscle phenotype, VEGF receptors, Sheep/embryology, Vascular Endothelial Growth Factor A/pharmacology, Fetus/blood supply, Oxygen/metabolism, Arteries/embryology, Myosin Heavy Chains/genetics, Protein Transport, Pregnancy, Phthalazines/pharmacology, Animals, Hypoxia/physiopathology, Female, Receptors, Vascular Endothelial Growth Factor/antagonists \& inhibitors, Protein Kinase Inhibitors/pharmacology, Pyridines/pharmacology",
author = "Hubbell, \{Margaret C.\} and Semotiuk, \{Andrew J.\} and Thorpe, \{Richard B.\} and Adeoye, \{Olayemi O.\} and Butler, \{Stacy M.\} and Williams, \{James M.\} and Omid Khorram and Pearce, \{William J.\}",
note = "Chronic hypoxia increases vascular endothelial growth factor (VEGF) and thereby promotes angiogenesis. The present study explores the hypothesis that hypoxic increases in VEGF also remodel artery wall structure and contractility through phenotypic transformation of smooth muscle. Pregnant and nonpregnant ewes were maintained at sea level (normoxia) or 3,820 m (hypoxia) for the final 110 days of gestation.",
year = "2012",
month = nov,
day = "15",
doi = "10.1152/ajpcell.00408.2011",
language = "English",
volume = "303",
pages = "C1090--C1103",
journal = "American Journal of Physiology - Cell Physiology",
issn = "0363-6143",
number = "10",
}