Chronic Cough Related to Acute Viral Bronchiolitis in Children: CHEST Expert Panel Report

Anne B. Chang; John J. Oppenheimer; Bruce K. Rubin; Miles Weinberger; Richard S. Irwin; Todd M. Adams; Kenneth W. Altman; Elie Azoulay; Alan F. Barker; Surinder S. Birring; Fiona Blackhall; Donald C. Bolser; Louis-Philippe Boulet; Sidney S. Braman; Christopher Brightling; Priscilla Callahan-Lyon; Terrie Cowley; Paul Davenport; Satoru Ebihara; Ali A. El Solh; Patricio Escalante; Stephen K. Field; Dina Fisher; Cynthia T. French; Peter Gibson; Philip M. Gold; Susan M. Harding; Anthony Harnden; Adam T. Hill; Peter J. Kahrilas; Joanne Kavanagh; Karina A. Keogh; Kefang Lai; Andrew P. Lane; Kaiser Lim; J. Mark Madison; Mark A. Malesker; Stuart Mazzone; Lorcan McGarvey; Joshua P. Metlay; Alex Molasoitis; Abigail Moore; M. Hassan Murad; Mangala Narasimhan; Huong Q. Nguyen; Peter Newcombe; John Oppenheimer; Marcos I. Restrepo; Mark Rosen

doi:10.1016/j.chest.2018.04.019

Chronic Cough Related to Acute Viral Bronchiolitis in Children: CHEST Expert Panel Report

Anne B. Chang, John J. Oppenheimer, Bruce K. Rubin, Miles Weinberger, Richard S. Irwin, Todd M. Adams, Kenneth W. Altman, Elie Azoulay, Alan F. Barker, Surinder S. Birring, Fiona Blackhall, Donald C. Bolser, Louis-Philippe Boulet, Sidney S. Braman, Christopher Brightling, Priscilla Callahan-Lyon, Terrie Cowley, Paul Davenport, Satoru Ebihara, Ali A. El SolhPatricio Escalante, Stephen K. Field, Dina Fisher, Cynthia T. French, Peter Gibson, Philip M. Gold, Susan M. Harding, Anthony Harnden, Adam T. Hill, Peter J. Kahrilas, Joanne Kavanagh, Karina A. Keogh, Kefang Lai, Andrew P. Lane, Kaiser Lim, J. Mark Madison, Mark A. Malesker, Stuart Mazzone, Lorcan McGarvey, Joshua P. Metlay, Alex Molasoitis, Abigail Moore, M. Hassan Murad, Mangala Narasimhan, Huong Q. Nguyen, Peter Newcombe, John Oppenheimer, Marcos I. Restrepo, Mark Rosen

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic reviews based on key questions (KQs) using the PICO (Population, Intervention, Comparison, Outcome) format. The KQs were: Among children with chronic cough (> 4 weeks) after acute viral bronchiolitis, how effective are the following interventions in improving the resolution of cough?: (1) Antibiotics. If so what type and for how long? (2) Asthma medications (inhaled steroids, beta2 agonist, montelukast); and (3) Inhaled osmotic agents like hypertonic saline? Methods: We used the CHEST expert cough panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form these suggestions. Delphi methodology was used to obtain consensus. Results: Several studies and systematic reviews on the efficacy of the three types of interventions listed in the introduction were found but no data were relevant to our KQs. Thus, no recommendations on using the interventions above could be formulated. Conclusions: The panel made several consensus-based suggestions and identified directions for future studies to advance the field of managing chronic cough post-acute bronchiolitis in children.

Original language	American English
Pages (from-to)	378-382
Number of pages	5
Journal	Chest
Volume	154
Issue number	2
DOIs	https://doi.org/10.1016/j.chest.2018.04.019 https://doi.org/10.1016/j.chest.2018.04.019
State	Published - Aug 1 2018

ASJC Scopus Subject Areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

Keywords

cough
evidence-based medicine
guidelines
Acute Disease
Humans
Bronchiolitis, Viral/drug therapy
Evidence-Based Medicine
Consensus
Delphi Technique
Cough/drug therapy
Child
Chronic Disease
Practice Guidelines as Topic

Disciplines

Medicine and Health Sciences
Critical Care

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Chang, A. B., Oppenheimer, J. J., Rubin, B. K., Weinberger, M., Irwin, R. S., Adams, T. M., Altman, K. W., Azoulay, E., Barker, A. F., Birring, S. S., Blackhall, F., Bolser, D. C., Boulet, L.-P., Braman, S. S., Brightling, C., Callahan-Lyon, P., Cowley, T., Davenport, P., Ebihara, S., ... Rosen, M. (2018). Chronic Cough Related to Acute Viral Bronchiolitis in Children: CHEST Expert Panel Report. Chest, 154(2), 378-382. https://doi.org/10.1016/j.chest.2018.04.019, https://doi.org/10.1016/j.chest.2018.04.019

Chang, AB, Oppenheimer, JJ, Rubin, BK, Weinberger, M, Irwin, RS, Adams, TM, Altman, KW, Azoulay, E, Barker, AF, Birring, SS, Blackhall, F, Bolser, DC, Boulet, L-P, Braman, SS, Brightling, C, Callahan-Lyon, P, Cowley, T, Davenport, P, Ebihara, S, Solh, AAE, Escalante, P, Field, SK, Fisher, D, French, CT, Gibson, P, Gold, PM, Harding, SM, Harnden, A, Hill, AT, Kahrilas, PJ, Kavanagh, J, Keogh, KA, Lai, K, Lane, AP, Lim, K, Madison, JM, Malesker, MA, Mazzone, S, McGarvey, L, Metlay, JP, Molasoitis, A, Moore, A, Murad, MH, Narasimhan, M, Nguyen, HQ, Newcombe, P, Oppenheimer, J, Restrepo, MI & Rosen, M 2018, 'Chronic Cough Related to Acute Viral Bronchiolitis in Children: CHEST Expert Panel Report', Chest, vol. 154, no. 2, pp. 378-382. https://doi.org/10.1016/j.chest.2018.04.019, https://doi.org/10.1016/j.chest.2018.04.019

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title = "Chronic Cough Related to Acute Viral Bronchiolitis in Children: CHEST Expert Panel Report",

abstract = "Background: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic reviews based on key questions (KQs) using the PICO (Population, Intervention, Comparison, Outcome) format. The KQs were: Among children with chronic cough (> 4 weeks) after acute viral bronchiolitis, how effective are the following interventions in improving the resolution of cough?: (1) Antibiotics. If so what type and for how long? (2) Asthma medications (inhaled steroids, beta2 agonist, montelukast); and (3) Inhaled osmotic agents like hypertonic saline? Methods: We used the CHEST expert cough panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework. Data from the systematic reviews in conjunction with patients{\textquoteright} values and preferences and the clinical context were used to form these suggestions. Delphi methodology was used to obtain consensus. Results: Several studies and systematic reviews on the efficacy of the three types of interventions listed in the introduction were found but no data were relevant to our KQs. Thus, no recommendations on using the interventions above could be formulated. Conclusions: The panel made several consensus-based suggestions and identified directions for future studies to advance the field of managing chronic cough post-acute bronchiolitis in children.",

keywords = "cough, evidence-based medicine, guidelines, Acute Disease, Humans, Bronchiolitis, Viral/drug therapy, Evidence-Based Medicine, Consensus, Delphi Technique, Cough/drug therapy, Child, Chronic Disease, Practice Guidelines as Topic",

author = "Chang, {Anne B.} and Oppenheimer, {John J.} and Rubin, {Bruce K.} and Miles Weinberger and Irwin, {Richard S.} and Adams, {Todd M.} and Altman, {Kenneth W.} and Elie Azoulay and Barker, {Alan F.} and Birring, {Surinder S.} and Fiona Blackhall and Bolser, {Donald C.} and Louis-Philippe Boulet and Braman, {Sidney S.} and Christopher Brightling and Priscilla Callahan-Lyon and Terrie Cowley and Paul Davenport and Satoru Ebihara and Solh, {Ali A. El} and Patricio Escalante and Field, {Stephen K.} and Dina Fisher and French, {Cynthia T.} and Peter Gibson and Gold, {Philip M.} and Harding, {Susan M.} and Anthony Harnden and Hill, {Adam T.} and Kahrilas, {Peter J.} and Joanne Kavanagh and Keogh, {Karina A.} and Kefang Lai and Lane, {Andrew P.} and Kaiser Lim and Madison, {J. Mark} and Malesker, {Mark A.} and Stuart Mazzone and Lorcan McGarvey and Metlay, {Joshua P.} and Alex Molasoitis and Abigail Moore and Murad, {M. Hassan} and Mangala Narasimhan and Nguyen, {Huong Q.} and Peter Newcombe and John Oppenheimer and Restrepo, {Marcos I.} and Mark Rosen",

note = "Publisher Copyright: {\textcopyright} 2018 American College of Chest Physicians",

year = "2018",

month = aug,

day = "1",

doi = "10.1016/j.chest.2018.04.019",

language = "American English",

volume = "154",

pages = "378--382",

journal = "Chest",

issn = "0012-3692",

number = "2",

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TY - JOUR

T1 - Chronic Cough Related to Acute Viral Bronchiolitis in Children

T2 - CHEST Expert Panel Report

AU - Chang, Anne B.

AU - Oppenheimer, John J.

AU - Rubin, Bruce K.

AU - Weinberger, Miles

AU - Irwin, Richard S.

AU - Adams, Todd M.

AU - Altman, Kenneth W.

AU - Azoulay, Elie

AU - Barker, Alan F.

AU - Birring, Surinder S.

AU - Blackhall, Fiona

AU - Bolser, Donald C.

AU - Boulet, Louis-Philippe

AU - Braman, Sidney S.

AU - Brightling, Christopher

AU - Callahan-Lyon, Priscilla

AU - Cowley, Terrie

AU - Davenport, Paul

AU - Ebihara, Satoru

AU - Solh, Ali A. El

AU - Escalante, Patricio

AU - Field, Stephen K.

AU - Fisher, Dina

AU - French, Cynthia T.

AU - Gibson, Peter

AU - Gold, Philip M.

AU - Harding, Susan M.

AU - Harnden, Anthony

AU - Hill, Adam T.

AU - Kahrilas, Peter J.

AU - Kavanagh, Joanne

AU - Keogh, Karina A.

AU - Lai, Kefang

AU - Lane, Andrew P.

AU - Lim, Kaiser

AU - Madison, J. Mark

AU - Malesker, Mark A.

AU - Mazzone, Stuart

AU - McGarvey, Lorcan

AU - Metlay, Joshua P.

AU - Molasoitis, Alex

AU - Moore, Abigail

AU - Murad, M. Hassan

AU - Narasimhan, Mangala

AU - Nguyen, Huong Q.

AU - Newcombe, Peter

AU - Oppenheimer, John

AU - Restrepo, Marcos I.

AU - Rosen, Mark

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic reviews based on key questions (KQs) using the PICO (Population, Intervention, Comparison, Outcome) format. The KQs were: Among children with chronic cough (> 4 weeks) after acute viral bronchiolitis, how effective are the following interventions in improving the resolution of cough?: (1) Antibiotics. If so what type and for how long? (2) Asthma medications (inhaled steroids, beta2 agonist, montelukast); and (3) Inhaled osmotic agents like hypertonic saline? Methods: We used the CHEST expert cough panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form these suggestions. Delphi methodology was used to obtain consensus. Results: Several studies and systematic reviews on the efficacy of the three types of interventions listed in the introduction were found but no data were relevant to our KQs. Thus, no recommendations on using the interventions above could be formulated. Conclusions: The panel made several consensus-based suggestions and identified directions for future studies to advance the field of managing chronic cough post-acute bronchiolitis in children.

AB - Background: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic reviews based on key questions (KQs) using the PICO (Population, Intervention, Comparison, Outcome) format. The KQs were: Among children with chronic cough (> 4 weeks) after acute viral bronchiolitis, how effective are the following interventions in improving the resolution of cough?: (1) Antibiotics. If so what type and for how long? (2) Asthma medications (inhaled steroids, beta2 agonist, montelukast); and (3) Inhaled osmotic agents like hypertonic saline? Methods: We used the CHEST expert cough panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form these suggestions. Delphi methodology was used to obtain consensus. Results: Several studies and systematic reviews on the efficacy of the three types of interventions listed in the introduction were found but no data were relevant to our KQs. Thus, no recommendations on using the interventions above could be formulated. Conclusions: The panel made several consensus-based suggestions and identified directions for future studies to advance the field of managing chronic cough post-acute bronchiolitis in children.

KW - cough

KW - evidence-based medicine

KW - guidelines

KW - Acute Disease

KW - Humans

KW - Bronchiolitis, Viral/drug therapy

KW - Evidence-Based Medicine

KW - Consensus

KW - Delphi Technique

KW - Cough/drug therapy

KW - Child

KW - Chronic Disease

KW - Practice Guidelines as Topic

UR - https://www.sciencedirect.com/science/article/pii/S0012369218306329

U2 - 10.1016/j.chest.2018.04.019

DO - 10.1016/j.chest.2018.04.019

M3 - Article

C2 - 29704475

SN - 0012-3692

VL - 154

SP - 378

EP - 382

JO - Chest

JF - Chest

IS - 2

ER -

Chronic Cough Related to Acute Viral Bronchiolitis in Children: CHEST Expert Panel Report

Abstract

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Keywords

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