Chromatin-modifying enzymes as modulators of reprogramming

Tamer T. Onder; Nergis Kara; Anne Cherry; Amit U. Sinha; Nan Zhu; Kathrin M. Bernt; Patrick Cahan; B. Ogan Marcarci; Juli Unternaehrer; Piyush B. Gupta; Eric S. Lander; Scott A. Armstrong; George Q. Daley

doi:10.1038/nature10953

Chromatin-modifying enzymes as modulators of reprogramming

Tamer T. Onder
, Nergis Kara
, Anne Cherry
, Amit U. Sinha
, Nan Zhu
, Kathrin M. Bernt
, Patrick Cahan
, B. Ogan Marcarci
, Juli Unternaehrer
, Piyush B. Gupta
, Eric S. Lander
, Scott A. Armstrong
, George Q. Daley

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	598-602
Number of pages	5
Journal	Nature
Volume	483
Issue number	7391
DOIs	https://doi.org/10.1038/nature10953
State	Published - Mar 4 2012
Externally published	Yes

ASJC Scopus Subject Areas

General

Keywords

Kruppel-Like Factor 4
Nanog Homeobox Protein
Histone-Lysine N-Methyltransferase
Homeodomain Proteins/metabolism
Fibroblasts/cytology
Humans
YY1 Transcription Factor/antagonists & inhibitors
DNA-Binding Proteins/antagonists & inhibitors
DNA Methylation/genetics
Proto-Oncogene Proteins c-myc/metabolism
Polycomb-Group Proteins
Enhancer of Zeste Homolog 2 Protein
Histones/metabolism
Induced Pluripotent Stem Cells/cytology
RNA-Binding Proteins/metabolism
Polycomb Repressive Complex 2
Transcription Factors/antagonists & inhibitors
Cellular Reprogramming/genetics
Methyltransferases/antagonists & inhibitors
Chromatin/genetics
RNA, Small Interfering
Kruppel-Like Transcription Factors/metabolism
Methylation
Repressor Proteins/antagonists & inhibitors

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10.1038/nature10953

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Cite this

@article{5ac9aaf335af44ae9ecf596ccca3e7b8,

title = "Chromatin-modifying enzymes as modulators of reprogramming",

keywords = "Kruppel-Like Factor 4, Nanog Homeobox Protein, Histone-Lysine N-Methyltransferase, Homeodomain Proteins/metabolism, Fibroblasts/cytology, Humans, YY1 Transcription Factor/antagonists \& inhibitors, DNA-Binding Proteins/antagonists \& inhibitors, DNA Methylation/genetics, Proto-Oncogene Proteins c-myc/metabolism, Polycomb-Group Proteins, Enhancer of Zeste Homolog 2 Protein, Histones/metabolism, Induced Pluripotent Stem Cells/cytology, RNA-Binding Proteins/metabolism, Polycomb Repressive Complex 2, Transcription Factors/antagonists \& inhibitors, Cellular Reprogramming/genetics, Methyltransferases/antagonists \& inhibitors, Chromatin/genetics, RNA, Small Interfering, Kruppel-Like Transcription Factors/metabolism, Methylation, Repressor Proteins/antagonists \& inhibitors",

author = "Onder, \{Tamer T.\} and Nergis Kara and Anne Cherry and Sinha, \{Amit U.\} and Nan Zhu and Bernt, \{Kathrin M.\} and Patrick Cahan and Marcarci, \{B. Ogan\} and Juli Unternaehrer and Gupta, \{Piyush B.\} and Lander, \{Eric S.\} and Armstrong, \{Scott A.\} and Daley, \{George Q.\}",

note = "Funding Information: Acknowledgements We thank G. Hu and S. J. Elledge for providing the MSCV-PM vector, K. Ng and M. W. Lensch for teratoma injections and assessment and S. Loewer for discussions. We also thank E. Olhava and Epizyme Inc. for synthesizing and providing the DOT1L inhibitor, EPZ004777. G.Q.D. is an investigator of the Howard Hughes Medical Institute. Research was funded by grants from the US National Institutes of Health (NIH) to S.A.A. (CA140575) and G.Q.D., and the CHB Stem Cell Program.",

year = "2012",

month = mar,

day = "4",

doi = "10.1038/nature10953",

language = "English",

volume = "483",

pages = "598--602",

journal = "Nature",

issn = "0028-0836",

number = "7391",

}

TY - JOUR

T1 - Chromatin-modifying enzymes as modulators of reprogramming

AU - Onder, Tamer T.

AU - Kara, Nergis

AU - Cherry, Anne

AU - Sinha, Amit U.

AU - Zhu, Nan

AU - Bernt, Kathrin M.

AU - Cahan, Patrick

AU - Marcarci, B. Ogan

AU - Unternaehrer, Juli

AU - Gupta, Piyush B.

AU - Lander, Eric S.

AU - Armstrong, Scott A.

AU - Daley, George Q.

N1 - Funding Information: Acknowledgements We thank G. Hu and S. J. Elledge for providing the MSCV-PM vector, K. Ng and M. W. Lensch for teratoma injections and assessment and S. Loewer for discussions. We also thank E. Olhava and Epizyme Inc. for synthesizing and providing the DOT1L inhibitor, EPZ004777. G.Q.D. is an investigator of the Howard Hughes Medical Institute. Research was funded by grants from the US National Institutes of Health (NIH) to S.A.A. (CA140575) and G.Q.D., and the CHB Stem Cell Program.

PY - 2012/3/4

Y1 - 2012/3/4

KW - Kruppel-Like Factor 4

KW - Nanog Homeobox Protein

KW - Histone-Lysine N-Methyltransferase

KW - Homeodomain Proteins/metabolism

KW - Fibroblasts/cytology

KW - Humans

KW - YY1 Transcription Factor/antagonists & inhibitors

KW - DNA-Binding Proteins/antagonists & inhibitors

KW - DNA Methylation/genetics

KW - Proto-Oncogene Proteins c-myc/metabolism

KW - Polycomb-Group Proteins

KW - Enhancer of Zeste Homolog 2 Protein

KW - Histones/metabolism

KW - Induced Pluripotent Stem Cells/cytology

KW - RNA-Binding Proteins/metabolism

KW - Polycomb Repressive Complex 2

KW - Transcription Factors/antagonists & inhibitors

KW - Cellular Reprogramming/genetics

KW - Methyltransferases/antagonists & inhibitors

KW - Chromatin/genetics

KW - RNA, Small Interfering

KW - Kruppel-Like Transcription Factors/metabolism

KW - Methylation

KW - Repressor Proteins/antagonists & inhibitors

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UR - https://www.scopus.com/pages/publications/84859218238#tab=citedBy

UR - https://www.mendeley.com/catalogue/6074da0c-1f75-3853-866c-707ec2c0c553/

U2 - 10.1038/nature10953

DO - 10.1038/nature10953

M3 - Article

C2 - 22388813

AN - SCOPUS:84859218238

SN - 0028-0836

VL - 483

SP - 598

EP - 602

JO - Nature

JF - Nature

IS - 7391

ER -

Chromatin-modifying enzymes as modulators of reprogramming

ASJC Scopus Subject Areas

Keywords

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