Chemical sympathectomy alters numbers of splenic and peritoneal leukocytes

P. A. Rice; G. W. Boehm; J. A. Moynihan; D. L. Bellinger; S. Y. Stevens

doi:10.1006/brbi.2000.0611

Chemical sympathectomy alters numbers of splenic and peritoneal leukocytes

P. A. Rice, G. W. Boehm, J. A. Moynihan, D. L. Bellinger, S. Y. Stevens

Anatomy Division

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Abstract

Sympathectomy of BALB/c mice that were injected with either Listeria monocytogenes or saline did not affect the total number of splenic leukocytes measured 1-3 days after injection, but sympathectomy did increase the percentages of neutrophils in the spleens of both infected and uninfected mice. By contrast, sympathectomy was associated with increased numbers of peritoneal exudate cells (PEC) and peritoneal macrophages in both groups of mice. Sympathectomy did not affect tumor necrosis factor-α, interleukin-12, or interferon-γ production in cultured splenocytes or PEC in either infected or uninfected mice.

Original language	English
Pages (from-to)	62-73
Number of pages	12
Journal	Brain, Behavior, and Immunity
Volume	16
Issue number	1
DOIs	https://doi.org/10.1006/brbi.2000.0611
State	Published - 2002

ASJC Scopus Subject Areas

Immunology
Endocrine and Autonomic Systems
Behavioral Neuroscience

Keywords

Innate immunity
Listeria
PEC
Peritoneum
Spleen
Sympathectomy

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title = "Chemical sympathectomy alters numbers of splenic and peritoneal leukocytes",

abstract = "Sympathectomy of BALB/c mice that were injected with either Listeria monocytogenes or saline did not affect the total number of splenic leukocytes measured 1-3 days after injection, but sympathectomy did increase the percentages of neutrophils in the spleens of both infected and uninfected mice. By contrast, sympathectomy was associated with increased numbers of peritoneal exudate cells (PEC) and peritoneal macrophages in both groups of mice. Sympathectomy did not affect tumor necrosis factor-α, interleukin-12, or interferon-γ production in cultured splenocytes or PEC in either infected or uninfected mice.",

keywords = "Innate immunity, Listeria, PEC, Peritoneum, Spleen, Sympathectomy",

author = "Rice, {P. A.} and Boehm, {G. W.} and Moynihan, {J. A.} and Bellinger, {D. L.} and Stevens, {S. Y.}",

note = "Funding Information: I thank the following people for technical assistance: John Housel, Tracey Smith, Sandra Lee, Dr. Barbara Kruszewska, Dr. S. Thyagarajan, and Dr. Kelley Madden. I also thank Dr. Jeffrey Hasday for editorial assistance. This work was supported by NIMH Grant R37MH42076.",

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AU - Boehm, G. W.

AU - Moynihan, J. A.

AU - Bellinger, D. L.

AU - Stevens, S. Y.

N1 - Funding Information: I thank the following people for technical assistance: John Housel, Tracey Smith, Sandra Lee, Dr. Barbara Kruszewska, Dr. S. Thyagarajan, and Dr. Kelley Madden. I also thank Dr. Jeffrey Hasday for editorial assistance. This work was supported by NIMH Grant R37MH42076.

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AB - Sympathectomy of BALB/c mice that were injected with either Listeria monocytogenes or saline did not affect the total number of splenic leukocytes measured 1-3 days after injection, but sympathectomy did increase the percentages of neutrophils in the spleens of both infected and uninfected mice. By contrast, sympathectomy was associated with increased numbers of peritoneal exudate cells (PEC) and peritoneal macrophages in both groups of mice. Sympathectomy did not affect tumor necrosis factor-α, interleukin-12, or interferon-γ production in cultured splenocytes or PEC in either infected or uninfected mice.

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KW - Spleen

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Chemical sympathectomy alters numbers of splenic and peritoneal leukocytes

Abstract

ASJC Scopus Subject Areas

Keywords

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