Chemical IN04 inhibits the kinase domain not the ROC domain of lrrk1: Results from homology modeling and molecular docking

Zhenhang Chen, Weirong Xing, Li Fan

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1140-1150
Number of pages11
JournalMedicinal Chemistry
Volume17
Issue number10
DOIs
StatePublished - Dec 2021

ASJC Scopus Subject Areas

  • Drug Discovery

Keywords

  • Bone loss
  • Homology model
  • IN04
  • Kinase inhibitor
  • Leucine rich repeat kinase 1
  • Molecular docking
  • ROC GTPase
  • Humans
  • Phylogeny
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics
  • Protein Kinases
  • Aged
  • Molecular Docking Simulation
  • Protein Serine-Threonine Kinases/genetics

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