Cerebral Small Vessel Disease

Qian Li; Yang Yang; Cesar Reis; Tao Tao; Wanwei Li; Xiaogang Li; John H. Zhang

doi:10.1177/0963689718795148

Cerebral Small Vessel Disease

Qian Li
, Yang Yang
, Cesar Reis
, Tao Tao
, Wanwei Li
, Xiaogang Li
, John H. Zhang

Research output: Contribution to journal › Review article › peer-review

Abstract

Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological processes and etiologies. Neuroimaging features of CSVD include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. The main clinical manifestations of CSVD include stroke, cognitive decline, dementia, psychiatric disorders, abnormal gait, and urinary incontinence. Currently, there are no specific preventive or therapeutic measures to improve this condition. In this review, we will discuss the pathophysiology, clinical aspects, neuroimaging, progress of research to treat and prevent CSVD and current treatment of this disease.

Original language	English
Pages (from-to)	1711-1722
Number of pages	12
Journal	Cell Transplantation
Volume	27
Issue number	12
DOIs	https://doi.org/10.1177/0963689718795148
State	Published - Dec 1 2018

ASJC Scopus Subject Areas

Biomedical Engineering
Cell Biology
Transplantation

Keywords

Cerebral small vessel disease
MRI
arteriolosclerosis
cerebral amyloid angiopathy
dementia
neuroimaging
stroke syndrome

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title = "Cerebral Small Vessel Disease",

abstract = "Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological processes and etiologies. Neuroimaging features of CSVD include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. The main clinical manifestations of CSVD include stroke, cognitive decline, dementia, psychiatric disorders, abnormal gait, and urinary incontinence. Currently, there are no specific preventive or therapeutic measures to improve this condition. In this review, we will discuss the pathophysiology, clinical aspects, neuroimaging, progress of research to treat and prevent CSVD and current treatment of this disease.",

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AU - Li, Qian

AU - Yang, Yang

AU - Reis, Cesar

AU - Tao, Tao

AU - Li, Wanwei

AU - Li, Xiaogang

AU - Zhang, John H.

N1 - Publisher Copyright: © The Author(s) 2018.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological processes and etiologies. Neuroimaging features of CSVD include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. The main clinical manifestations of CSVD include stroke, cognitive decline, dementia, psychiatric disorders, abnormal gait, and urinary incontinence. Currently, there are no specific preventive or therapeutic measures to improve this condition. In this review, we will discuss the pathophysiology, clinical aspects, neuroimaging, progress of research to treat and prevent CSVD and current treatment of this disease.

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KW - cerebral amyloid angiopathy

KW - dementia

KW - neuroimaging

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Cerebral Small Vessel Disease

Abstract

ASJC Scopus Subject Areas

Keywords

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