Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers

Ioannis Pappas; Trevor Lohman; Shubir Dutt; Arunima Kapoor; Allison C. Engstrom; John Paul M. Alitin; Samuel Barnes; Ararat Chakhoyan; Lucas Saca; Raghav Gaggar; Elnaz Nourollahimoghadam; Danny J.J. Wang; Mark H.C. Lai; Elizabeth B. Joe; John M. Ringman; Hussein N. Yassine; Lon S. Schneider; Helena C. Chui; Arthur W. Toga; Berislav V. Zlokovic; Daniel A. Nation

doi:10.1007/s11357-025-01642-5

Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers

Ioannis Pappas
, Trevor Lohman
, Shubir Dutt
, Arunima Kapoor
, Allison C. Engstrom
, John Paul M. Alitin
, Samuel Barnes
, Ararat Chakhoyan
, Lucas Saca
, Raghav Gaggar
, Elnaz Nourollahimoghadam
, Danny J.J. Wang
, Mark H.C. Lai
, Elizabeth B. Joe
, John M. Ringman
, Hussein N. Yassine
, Lon S. Schneider
, Helena C. Chui
, Arthur W. Toga
, Berislav V. Zlokovic

Daniel A. Nation

Radiology

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	4973-4986
Number of pages	14
Journal	GeroScience
Volume	47
Issue number	3
DOIs	https://doi.org/10.1007/s11357-025-01642-5
State	Published - Jun 2025

ASJC Scopus Subject Areas

Aging
veterinary (miscalleneous)
Complementary and alternative medicine
Geriatrics and Gerontology
Cardiology and Cardiovascular Medicine

Keywords

Apolipoprotein E
Brain atrophy
Cerebral blood flow
White matter integrity
Humans
Middle Aged
Male
Gray Matter/diagnostic imaging
White Matter/diagnostic imaging
Apolipoprotein E4/genetics
Neuropsychological Tests
Magnetic Resonance Imaging
Brain/pathology
Cognitive Dysfunction/genetics
Cerebrovascular Circulation/physiology
Aged, 80 and over
Female
Heterozygote
Aged

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Pappas, I., Lohman, T., Dutt, S., Kapoor, A., Engstrom, A. C., Alitin, J. P. M., Barnes, S., Chakhoyan, A., Saca, L., Gaggar, R., Nourollahimoghadam, E., Wang, D. J. J., Lai, M. H. C., Joe, E. B., Ringman, J. M., Yassine, H. N., Schneider, L. S., Chui, H. C., Toga, A. W., ... Nation, D. A. (2025). Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers. GeroScience, 47(3), 4973-4986. https://doi.org/10.1007/s11357-025-01642-5

Pappas, I, Lohman, T, Dutt, S, Kapoor, A, Engstrom, AC, Alitin, JPM, Barnes, S, Chakhoyan, A, Saca, L, Gaggar, R, Nourollahimoghadam, E, Wang, DJJ, Lai, MHC, Joe, EB, Ringman, JM, Yassine, HN, Schneider, LS, Chui, HC, Toga, AW, Zlokovic, BV & Nation, DA 2025, 'Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers', GeroScience, vol. 47, no. 3, pp. 4973-4986. https://doi.org/10.1007/s11357-025-01642-5

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AU - Pappas, Ioannis

AU - Lohman, Trevor

AU - Dutt, Shubir

AU - Kapoor, Arunima

AU - Engstrom, Allison C.

AU - Alitin, John Paul M.

AU - Barnes, Samuel

AU - Chakhoyan, Ararat

AU - Saca, Lucas

AU - Gaggar, Raghav

AU - Nourollahimoghadam, Elnaz

AU - Wang, Danny J.J.

AU - Lai, Mark H.C.

AU - Joe, Elizabeth B.

AU - Ringman, John M.

AU - Yassine, Hussein N.

AU - Schneider, Lon S.

AU - Chui, Helena C.

AU - Toga, Arthur W.

AU - Zlokovic, Berislav V.

AU - Nation, Daniel A.

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KW - Cerebral blood flow

KW - White matter integrity

KW - Humans

KW - Middle Aged

KW - Male

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KW - Apolipoprotein E4/genetics

KW - Neuropsychological Tests

KW - Magnetic Resonance Imaging

KW - Brain/pathology

KW - Cognitive Dysfunction/genetics

KW - Cerebrovascular Circulation/physiology

KW - Aged, 80 and over

KW - Female

KW - Heterozygote

KW - Aged

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DO - 10.1007/s11357-025-01642-5

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Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers

ASJC Scopus Subject Areas

Keywords

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