Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Aβ1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease

Bilal Malik; Antonio Currais; Salvador Soriano

doi:10.1111/j.1471-4159.2008.05446.x

Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Aβ_1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease

Bilal Malik
, Antonio Currais
, Salvador Soriano

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	912-916
Number of pages	5
Journal	Journal of Neurochemistry
Volume	106
Issue number	2
DOIs	https://doi.org/10.1111/j.1471-4159.2008.05446.x
State	Published - Jul 2008
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Cellular and Molecular Neuroscience

Keywords

Alzheimer's disease
Cell cycle
Presenilin
Peptide Fragments/pharmacology
Up-Regulation/physiology
Embryo, Mammalian
Humans
Neurons/drug effects
Presenilin-1/genetics
Apoptosis/physiology
beta Catenin/metabolism
Amyloid beta-Peptides/pharmacology
Disease Models, Animal
Cell Cycle/physiology
Cerebral Cortex/pathology
Cyclin D1/metabolism
Alzheimer Disease/genetics
Mutation/genetics
Cells, Cultured
Mice, Transgenic
Bromodeoxyuridine/metabolism
Animals
Analysis of Variance
Hippocampus/metabolism
Mice

Access to Document

10.1111/j.1471-4159.2008.05446.x

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Cite this

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AU - Currais, Antonio

AU - Soriano, Salvador

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