CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells

Ying Bai; Hui Ren; Shuo Leng; Mengqin Yuan; Yi Xin Jiang; Shenyang Zhang; Yu Wang; Minzi Ju; Zhi Wang; Wen Xi; Lian Xu; Bingjing Zheng; Daxing Li; Xinchen Huo; Tianhao Zhu; Beicheng Zhang; Ling Shen; Yuan Zhang; Wei Jiang; John H. Zhang; Bing Han; Honghong Yao

doi:10.1038/s41423-025-01311-9

CD8⁺GZMK⁺CD27⁺CCR7⁺ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells

Ying Bai
, Hui Ren
, Shuo Leng
, Mengqin Yuan
, Yi Xin Jiang
, Shenyang Zhang
, Yu Wang
, Minzi Ju
, Zhi Wang
, Wen Xi
, Lian Xu
, Bingjing Zheng
, Daxing Li
, Xinchen Huo
, Tianhao Zhu
, Beicheng Zhang
, Ling Shen
, Yuan Zhang
, Wei Jiang
, John H. Zhang

Bing Han, Honghong Yao

Nursing - Graduate

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1061-1076
Number of pages	16
Journal	Cellular & molecular immunology
Volume	22
Issue number	9
DOIs	https://doi.org/10.1038/s41423-025-01311-9
State	Published - Sep 2025

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Infectious Diseases

Keywords

Acute ischemic stroke
CCL19
CCR7
Functional recovery
Splenic sympathetic denervation
Stroke-associated T cells

Access to Document

10.1038/s41423-025-01311-9

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Cite this

Bai, Y., Ren, H., Leng, S., Yuan, M., Jiang, Y. X., Zhang, S., Wang, Y., Ju, M., Wang, Z., Xi, W., Xu, L., Zheng, B., Li, D., Huo, X., Zhu, T., Zhang, B., Shen, L., Zhang, Y., Jiang, W., ... Yao, H. (2025). CD8⁺GZMK⁺CD27⁺CCR7⁺ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells. Cellular & molecular immunology, 22(9), 1061-1076. https://doi.org/10.1038/s41423-025-01311-9

Bai, Y, Ren, H, Leng, S, Yuan, M, Jiang, YX, Zhang, S, Wang, Y, Ju, M, Wang, Z, Xi, W, Xu, L, Zheng, B, Li, D, Huo, X, Zhu, T, Zhang, B, Shen, L, Zhang, Y, Jiang, W, Zhang, JH, Han, B & Yao, H 2025, 'CD8⁺GZMK⁺CD27⁺CCR7⁺ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells', Cellular & molecular immunology, vol. 22, no. 9, pp. 1061-1076. https://doi.org/10.1038/s41423-025-01311-9

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title = "CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells",

keywords = "Acute ischemic stroke, CCL19, CCR7, Functional recovery, Splenic sympathetic denervation, Stroke-associated T cells",

author = "Ying Bai and Hui Ren and Shuo Leng and Mengqin Yuan and Jiang, \{Yi Xin\} and Shenyang Zhang and Yu Wang and Minzi Ju and Zhi Wang and Wen Xi and Lian Xu and Bingjing Zheng and Daxing Li and Xinchen Huo and Tianhao Zhu and Beicheng Zhang and Ling Shen and Yuan Zhang and Wei Jiang and Zhang, \{John H.\} and Bing Han and Honghong Yao",

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doi = "10.1038/s41423-025-01311-9",

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AU - Bai, Ying

AU - Ren, Hui

AU - Leng, Shuo

AU - Yuan, Mengqin

AU - Jiang, Yi Xin

AU - Zhang, Shenyang

AU - Wang, Yu

AU - Ju, Minzi

AU - Wang, Zhi

AU - Xi, Wen

AU - Xu, Lian

AU - Zheng, Bingjing

AU - Li, Daxing

AU - Huo, Xinchen

AU - Zhu, Tianhao

AU - Zhang, Beicheng

AU - Shen, Ling

AU - Zhang, Yuan

AU - Jiang, Wei

AU - Zhang, John H.

AU - Han, Bing

AU - Yao, Honghong

PY - 2025/9

Y1 - 2025/9

KW - Acute ischemic stroke

KW - CCL19

KW - CCR7

KW - Functional recovery

KW - Splenic sympathetic denervation

KW - Stroke-associated T cells

UR - https://www.scopus.com/pages/publications/105010656137

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DO - 10.1038/s41423-025-01311-9

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