CCR5 activation promotes NLRP1-dependent neuronal pyroptosis via CCR5/PKA/CREB pathway after intracerebral hemorrhage

Jun Yan, Weilin Xu, Cameron Lenahan, Lei Huang, Jing Wen, Gaigai Li, Xin Hu, Wen Zheng, John H. Zhang, Jiping Tang

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)4021-4032
Number of pages12
JournalStroke
Volume52
Issue number12
DOIs
StatePublished - Dec 1 2021

ASJC Scopus Subject Areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Keywords

  • Cerebral hemorrhage
  • Chemokine receptor
  • Inflammasome
  • Neuron
  • Pyroptosis
  • Cyclic AMP Response Element-Binding Protein/metabolism
  • Pyroptosis/physiology
  • Cyclic AMP-Dependent Protein Kinases/metabolism
  • Male
  • Adaptor Proteins, Signal Transducing/metabolism
  • Signal Transduction/physiology
  • Animals
  • Neurons/metabolism
  • Cerebral Hemorrhage/metabolism
  • Mice
  • Apoptosis Regulatory Proteins/metabolism
  • Receptors, CCR5/metabolism

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