Caspase Inhibitors Prevent Endothelial Apoptosis and Cerebral Vasospasm in Dog Model of Experimental Subarachnoid Hemorrhage

Changman Zhou, Mitsuo Yamaguchi, Gen Kusaka, Claudio Schonholz, Anil Nanda, John H. Zhang

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)419-431
Number of pages13
JournalJournal of Cerebral Blood Flow and Metabolism
Volume24
Issue number4
DOIs
StatePublished - Apr 2004
Externally publishedYes

ASJC Scopus Subject Areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Keywords

  • Apoptosis
  • Caspase inhibitor
  • Cerebral vasospasm
  • Subazachnoid hemorrhage
  • Immunohistochemistry
  • In Situ Nick-End Labeling
  • Vasodilator Agents/therapeutic use
  • Caspase 8
  • Apoptosis/drug effects
  • Male
  • Caspase Inhibitors
  • Subarachnoid Hemorrhage/complications
  • Animals
  • Endothelium, Vascular/drug effects
  • Cerebral Angiography
  • Enzyme Inhibitors/therapeutic use
  • Basilar Artery/drug effects
  • Dogs
  • Caspase 3
  • Female
  • Vasospasm, Intracranial/enzymology
  • Receptors, Tumor Necrosis Factor/biosynthesis
  • Disease Models, Animal

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