BMS-470539 Attenuates Oxidative Stress and Neuronal Apoptosis via MC1R/cAMP/PKA/Nurr1 Signaling Pathway in a Neonatal Hypoxic-Ischemic Rat Model

Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yuanyuan Gao, Yong Guo, Zackary D. Travis, Jiping Tang, Wen Xiong Chen, John H. Zhang

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number4054938
JournalOxidative Medicine and Cellular Longevity
Volume2022
DOIs
StatePublished - Jan 31 2022

ASJC Scopus Subject Areas

  • Biochemistry
  • Aging
  • Cell Biology

Keywords

  • Animals, Newborn
  • Neuroprotective Agents/administration & dosage
  • Cyclic AMP-Dependent Protein Kinases/metabolism
  • Apoptosis/drug effects
  • Rats
  • Male
  • Treatment Outcome
  • Neurons/drug effects
  • Gene Knockout Techniques/methods
  • Administration, Intranasal
  • Rats, Sprague-Dawley
  • Signal Transduction/drug effects
  • Hypoxia-Ischemia, Brain/drug therapy
  • Oxidative Stress/drug effects
  • Antioxidants/administration & dosage
  • Animals
  • Nuclear Receptor Subfamily 4, Group A, Member 2/genetics
  • Receptor, Melanocortin, Type 1/agonists
  • Female
  • Cyclic AMP/metabolism
  • Imidazoles/administration & dosage

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