TY - JOUR
T1 - Biological correlates of QT interval and QT dispersion in 2, 265 patients with left ventricular ejection fraction ≤40%
AU - Pai, Ramdas G.
AU - Padmanabhan, Sriram
N1 - Increased QT interval and QT dispersion have been associated with increased mortality in a variety of cardiovascular disorders including heart failure...
PY - 2002/7
Y1 - 2002/7
N2 - Increased QT interval and QT dispersion have been associated with increased mortality in a variety of cardiovascular disorders including heart failure. However, the biological correlates of these abnormalities are not clear. QTc and QTd were measured in an automated fashion from digitized electrocardiograms in 2, 265 patients with an LV ejection fraction ≤40% and were related to clinical, electrocardiographic, and echocardiographic variables. The QTc interval increased with increasing age (P =.0003), heart rate (P <.0001), LV dimensions (P <.0001), left atrial diameter (P <.0001), estimated right atrial pressure (P <.0001), QRS duration (P <.0001), bundle branch blocks (P <.0001) and degree of mitral and tricuspid regurgitation (P <.0001) and decreasing LV ejection fraction (P <.0001) QT dispersion increased with increasing LV isovolumic relaxation time (P =.004) and QTc (P <.0001) and decreased with faster heart rate (P <.0001) and higher right atrial pressure (P =.0007). The biological relationships of QTc and QTd warrant further investigations.
AB - Increased QT interval and QT dispersion have been associated with increased mortality in a variety of cardiovascular disorders including heart failure. However, the biological correlates of these abnormalities are not clear. QTc and QTd were measured in an automated fashion from digitized electrocardiograms in 2, 265 patients with an LV ejection fraction ≤40% and were related to clinical, electrocardiographic, and echocardiographic variables. The QTc interval increased with increasing age (P =.0003), heart rate (P <.0001), LV dimensions (P <.0001), left atrial diameter (P <.0001), estimated right atrial pressure (P <.0001), QRS duration (P <.0001), bundle branch blocks (P <.0001) and degree of mitral and tricuspid regurgitation (P <.0001) and decreasing LV ejection fraction (P <.0001) QT dispersion increased with increasing LV isovolumic relaxation time (P =.004) and QTc (P <.0001) and decreased with faster heart rate (P <.0001) and higher right atrial pressure (P =.0007). The biological relationships of QTc and QTd warrant further investigations.
UR - https://www.scopus.com/pages/publications/0036076110
UR - https://www.scopus.com/pages/publications/0036076110#tab=citedBy
U2 - 10.1054/jelc.2002.33970
DO - 10.1054/jelc.2002.33970
M3 - Article
C2 - 12122612
SN - 0022-0736
VL - 35
SP - 223
EP - 226
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
IS - 3
ER -